Prolonged Decrease in Stress Reactivity Caused by Dehydroepiandrosterone Sulfate

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In male rats exposed to repeated stress, the decrease in stress reactivity produced by subcutaneous injection of dehydroepiandrosterone sulfate (recorded by the decrease in stress-induced concentrations of corticosterone and adrenocorticotropic hormone in blood plasma) was observed 1–6 days postinjection and involved central regulatory mechanisms.

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