Evaluation of the Progeny of Rats Treated with Topoisomerase II Inhibitor Vepesid

    loading  Checking for direct PDF access through Ovid

Abstract

Progeny of Wistar rats treated with vepesid 1, 3, and 6 months before mating is characterized by common pathological changes. These changes were more pronounced and more diverse in animals descending from females receiving the cytostatic compared to the progeny of treated males. The severity of toxic effects depended on the period between mating and vepesid treatment. Cytostatic treatment 3 months before mating was associated with minimum toxicity for the progeny.

Related Topics

    loading  Loading Related Articles