Effect of Nitroglycerine on Content of Second Messengers in Myocytes of Rat Thoracic Aorta

    loading  Checking for direct PDF access through Ovid


We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10−7 M). Under conditions of experimental nitrate tolerance the dose-dependent effect of nitroglycerine on intracellular cGMP and Ca2+ was less pronounced. Calcium-blocking activity of nitroglycerine decreased most significantly upon stimulation of myocytes with norepinephrine.

Related Topics

    loading  Loading Related Articles