Poly(ADP-Ribose)-Polymerase-1 and Aging: Experimental Study of Possible Relationship on Stationary Cell Cultures

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Abstract

Experiments on “stationary aging” cultures of B11dii-FAF28 Chinese hamster cells showed that contact inhibition of cell growth and further culturing of cells in the stationary phase led to continuous inhibition of enzymes realizing poly-ADP-ribosylation of chromatin proteins. Cell density in the monolayer and percentage of damaged cells detected by trypan blue staining decreases during this process.

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