Effect of GABAergic and Adrenergic Agents on Activity of Na+/K+ Pump and Cl−-Cotransport in Somatic Muscle Cells of Earthworm Lumbricus Terrestris

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Abstract

GABA, baclofen, epinephrine, and norepinephrine hyperpolarized the membrane of earthworm somatic cells. This effect was prevented by furosemide, removal of Cl− from the medium, or activation of Na+/K+ pump by 3-fold increase external potassium concentration. It was hypothesized that GABA, baclofen, epinephrine, and norepinephrine stimulate Na+/K+ transport via specific receptor inputs, but their effect on resting potential can be realized only under conditions of working Cl− symport.

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