Expression of Genes for Redox-Dependent Glutathione S-Transferase Isoforms GSTP1-1 and GSTA4-4 in Tumor Cell during the Development Doxorubicin Resistance

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Abstract

Expression of genes for redox-dependent glutathione S-transferase isoforms GSTP1-1 and GSTA4-4 in tumor cells K562, MCF-7, and SKOV-3 was studied during the development of resistance to doxorubicin. It was found that the development of resistance was accompanied by predominant increase in the expression of hGSTP1 gene in MCF-7 cells, and hGSTA4 gene in resistant K562/DOX and SKVLB cells.

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