Effect of Experimental Litter Reduction in Female Rats on Parameters of Brain and Endocrine Gland Development in the Progeny

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Abstract

We studied the relationship between parameters of brain development, elevated plusmaze behavior, and the status of the endocrine glands in the progeny of 4.5–5-and 8–9-month-old females after litter reduction by removal of one uterine tube. The progeny of young experimental females differed from the progeny of control animals by brain weight (at the age of 1 day), morphometrical characteristics of the cortex and its neurons, activity of 3β-hydroxysteroid dehydrogenase in the adrenal cortex (at the age of 1 and 40 days), and behavioral reactions in the elevated plus-maze (at the age of 30 days). The differences in these parameters between the progeny from old females with experimentally reduced litter size and control females were significantly less pronounced.

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