Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

    loading  Checking for direct PDF access through Ovid

Abstract

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.

Related Topics

    loading  Loading Related Articles