Automated measurement of stereotypic behavior in rats


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Abstract

Compared an animal activity monitoring system in which 2 of the motor variables measured constitute an index of stereotyped behaviors with a standard visual stereotypy rating scale following the administration of apomorphine or amphetamine. The automated measure “number of stereotypies” failed to show a significant dose-response effect with amphetamine, and the measure “stereotypy time” was less sensitive to the effects of apomorphine. The 2 measures, however, significantly correlated with the visual scales and, in combination, revealed the ongoing stereotypic effects of the drugs over time and thus eliminated confounding variables, such as experimenter bias, commonly associated with visual rating techniques. (6 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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