Pavlovian drug-sickness pairings result in the conditioning of an antisickness response


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Abstract

Previous findings indicate that after a drug CS has been injected prior to LiCl as the UCS on 5 occasions, the drug CS has the capability to evoke a conditioned antisickness response (CAR). This CAR is implied by the finding that the CS drug mitigates the conditioned saccharin aversion produced by Li when it is administered in the interval between saccharin consumption and Li injection. The present study, with 60 male Sprague-Dawley rats, tested the CAR hypothesis. The following drugs were tested and are listed in approximate order of their effectiveness in producing a conditioned antisickness effect: pentobarbital, ethanol, morphine, amphetamine, and chlordiazepoxide. (17 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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