Role of olfactory bulbectomy and DSP4 treatment in avoidance learning in the rat

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In 3 experiments with 101 male Sprague-Dawley rats, olfactory bulbectomized Ss and N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)-treated Ss were studied on a 2-way active avoidance task as well as on step-down passive avoidance and fear conditioning and retention tasks. The DSP4-treated, but not olfactory bulbectomized, Ss were impaired in acquiring 2-way avoidance; bulbectomized, but not DSP4-treated, Ss showed notable passive avoidance and fear retention deficits. Bulbectomized Ss treated with DSP4 did not show passive avoidance and fear retention deficits, nor did these Ss evidence the 2-way avoidance impairment of the DSP4-treated Ss. No alteration of dopamine-beta-hydroxylase activity in the frontal cortex and hippocampus as a result of the bulbectomy operation was indicated. The double dissociation between bulbectomized and DSP4-treated Ss is discussed in terms of opponent behavioral processes, influenced by olfactory bulbectomy and DSP4, which may permit insights into experimental investigations of stress, anxiety, and depression. (40 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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