The Entorhinal Cortex–Nucleus Accumbens Pathway and Latent Inhibition: A Behavioral and Neurochemical Study in Rats


    loading  Checking for direct PDF access through Ovid

Abstract

Latent inhibition (LI) refers to the decrease in conditioned response produced by the repeated nonreinforced preexposure to the to-be-conditioned stimulus. Experiment 1 investigated the effects of electrolytic lesions of the entorhinal cortex on LI in a conditioned emotional response procedure. Entorhinal cortex lesions attenuated LI. Experiments 2 and 3 investigated whether this attenuation of LI could result from a modification in nucleus accumbens (NAcc) dopamine (DA) release. Rats with entorhinal cortex lesions displayed normal spontaneous and amphetamine-induced locomotor activity, as well as normal basal and amphetamine-induced release of DA within the NAcc (assessed by microdialysis). Taken together, these results show that entorhinal cortex lesions disrupt LI in a way that is unlikely to be due to an alteration of DA release within the NAcc.

    loading  Loading Related Articles