The present communication describes the combination of molecularly imprinted SPE and dispersive liquid–liquid microextraction for the selective preconcentration and determination of telmisartan (TEL) in rat urine, plasma and pharmaceutical formulation by HPLC.Results:
Various factors that can affect the extraction efficiency of molecularly imprinted SPE and dispersive liquid–liquid microextraction were optimized. The LOD and LOQ were found to be 0.19 and 0.63 µg ml-1 in urine, while in plasma it was found to be 0.28 and 0.87 µg ml-1, respectively. The percentage recovery of TEL in different matrices was found to be in the range of 81–97%.Conclusion:
The proposed method may find wide applications in clinical, toxicological and QC laboratories for the routine analysis of TEL.