Screening of synthetic cannabinoids in preserved oral fluid by UPLC–MS/MS

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Abstract

Background:

The abuse of a rapidly changing range of synthetic cannabinoids is increasing worldwide. Oral fluid, which contains the parent compounds and is easily collected, could be a good alternative medium for drug screening for synthetic cannabinoids.

Results:

A method for screening of 18 synthetic cannabinoids in preserved oral fluid collected with the Intercept® collection device, using UPLC–MS/MS, was validated. Limits of quantification ranged from 0.2 to 2 ng/ml in oral fluid. In several real cases, AM-2201 and/or JWH-018 were found.

Conclusion:

The presented method allowed rapid and sensitive screening of synthetic cannabinoids in preserved oral fluid collected with the Intercept collection device.

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