Ultrasound assisted dispersive liquid–liquid microextraction followed by injector port silylation: a novel method for rapid determination of quinine in urine by GC–MS

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Abstract

Background:

Silylation is a widely used derivatization method for the analysis of polar analytes by GC–MS. Ultrasound-assisted dispersive liquid–liquid microextraction (UA-DLLME) is an ecofriendly, rapid and simple microextraction method. For the first time, a novel approach has been developed and applied for the analysis of quinine in urine by combining UA-DLLME with injection port silylation.

Results:

The LOD and LOQ were found to be 5.4 and 18 ng/ml. The intra- and inter-day precisions were less than 5 and 8%, respectively. Mean recoveries of quinine were found to be in the range of 87 to 96%.

Conclusion:

Ultrasound-assisted dispersive liquid–liquid microextraction is rapid, simple and consumes less reagent for the analysis of polar analytes such as quinine.

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