Nicotinic acetylcholine receptors as therapeutic targets: Emerging frontiers in basic research and clinical science—Editorial comments
Structural insights into Cys-loop receptor function and ligand recognition
Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies
Biogenesis, trafficking and up-regulation of nicotinic ACh receptors
Transcriptional regulation by nicotine in dopaminergic neurons
Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine
Nicotinic acetylcholine receptors controlling attention: Behavior, circuits and sensitivity to disruption by nicotine
α7 Nicotinic receptor agonist reactivates neurogenesis in adult brain ☆
Genetic matters: Thirty years of progress using mouse models in nicotinic research
Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors
Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia
Cognition as a therapeutic target in late-life depression: Potential for nicotinic therapeutics
Complex relationships of nicotinic receptor actions and cognitive functions
Multiple CNS nicotinic receptors mediate l-dopa-induced dyskinesias: Studies with parkinsonian nicotinic receptor knockout mice ☆
Nicotinic modulation of intrinsic brain networks in schizophrenia
Cortical control of VTA function and influence on nicotine reward
Potential substrates for nicotine and alcohol interactions: A focus on the mesocorticolimbic dopamine system
Nicotinic acetylcholine receptors containing the α6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons
Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: Studies in transgenic mice
Neuronal nicotinic receptors as analgesic targets: It's a winding road
Nicotine signaling and progression of chronic kidney disease in smokers
An additional binding site for methyllycaconitine (MLA) and analogs occurs at the α4–α4 interface of the (α4)3(β2)2 nAChR
Nicotine-induced subunit stoichiometry affects the stability and intracellular trafficking of α3β4 nicotinic receptors
Antipsychotic compounds show inhibition of the human nicotinic acetylcholine α-7 receptor at high concentrations
Effects of positive allosteric modulators (PAMs) of nicotinic receptors on intracellular Ca2+ concentration [Ca2+]i in mouse embryonic mesencephalic neurons in primary culture
Functional chimera of the human α7 acetylcholine receptor for mechanistic investigations of allosteric modulation
Structures of α7 and α4β2 nAChR transmenbrane domains and associated binding sites for allosteric modulators
Proteomic investigation of human α7-nicotinic acetylcholine receptor signaling mechanisms
Mining the depths of chemical space for new nicotinic ligands
In vitro exposure to nicotine modulate the function of presynaptic NMDA receptors present on dopaminergic terminals in rat Nucleus Accumbens
Nicotinic acetylcholine receptor regulation of striatal dopamine transmission: The different requirement for diverse subtypes in ventral versus dorsal striatum
Novel strategy of blocking nAChR revealed by dissecting a dimeric conotoxin αD-GeXXA
Does the β2 C loop of the neuronal nicotinic acetylcholine receptor dictate the type of allosteric modulation?
Dicarba modification of α-conotoxin RgIA conferring selectivity towards α9α10 nicotinic acetylcholine receptors
Dendritic spine density of prefrontal layer VI neurons is disrupted following chronic in vivo nicotine exposure in development
Region-specific cholinergic excitation of layer VI cortical neurons depends on receptor balance and chrna5 expression
Discovery of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration
Nicotinic α4β2 antagonist treatment attenuates impairments in radial-arm maze repeated acquisition caused by dizocilpine in rats
Characterization of BNC375, a novel α7 nAChR positive allosteric modulator for the treatment of cognitive impairment in Alzheimer's disease
Nicotine effects on time perception in rats
Nicotinic regulation in a hyperdopaminergic state
Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity
Pharmacokinetics and toxicity of a neuroprotective cembranoid
A Type-II positive allosteric modulator of α7 nAChRs significantly reduces brain injury and improves neurological function after focal cerebral ischemia in rats
Varenicline ameliorates spatial and temporal gait deficits following 3-acetylpyridine-induced ataxia in rats
Nicotine perturbs PFC–VTA coupling: A new mechanism for nicotine addiction
Pacemaking of midbrain habenular cholinergic neurons in nicotine withdrawal
Null mutation of the β2 nAChR subunit attenuated anhedonia induced by spontaneous and mecamylamine-precipitated nicotine withdrawal in mice
Nicotine decreases ethanol-induced dopamine signaling and increases ethanol self-administration via stress hormones
Cellular and synaptic mechanisms of nicotine aversion
Nicotinic receptor-mediated direct and indirect excitation of periaqueductal gray neurons that project to the rostral ventromedial medulla
Vestibular dysfunction in alpha9 and alpha9/10 knockout mice
The deletion of both the α9 and α10 nAChR subunits results in a different phenotype than the single deletion of the α9 or α10 subunit