Nicotinic acetylcholine receptors as therapeutic targets: Emerging frontiers in basic research and clinical science – Editorial Comments
The human clinical phenotypes of altered CHRNA7 copy number
The α7 nicotinic acetylcholine receptor: A mediator of pathogenesis and therapeutic target in autism spectrum disorders and Down syndrome
The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system
Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders
Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease
Allosteric modulation of nicotinic acetylcholine receptors
Long-lasting changes in neural networks to compensate for altered nicotinic input
Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors
The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus
Modulation of hippocampal neuronal network oscillations by α7 nACh receptors
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection
Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction
Nicotinic modulation of auditory evoked potential electroencephalography in a rodent neurodevelopmental model of schizophrenia
Modulation of aggressive behavior in mice by nicotinic receptor subtypes
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
T-cell receptors modify neuronal function in the central nervous system
UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP
High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice
Methadone's effect on nAChRs—a link between methadone use and smoking?
Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system
α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression
Development of [18F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography
Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays
The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain
Activation of endplate nicotinic acetylcholine receptors by agonists
AChR-specific immunosuppressive therapy of myasthenia gravis
Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor
Cyclic imine toxins: From shellfish poisoning to neuroscience: The case of acyl derivatives
Cellular and synaptic mechanisms of nicotine aversion
Development and validation of an α3β4 nicotinic acetylcholine receptor (nAChR) high-throughput screening- (HTS-) ready assay
Exploring the structure activity relationships of halogen containing N -(pyridin-3-yl)-piperazines and homopiperazines at α4β2 nAChRs
Modulation of α4β2 NACHRs via an extracellular binding site: Structural studies and novel engineered receptors to aid drug discovery
Exploiting ligand selectivity to understand allosteric receptor opening
Nicotine pretreatment alters the responses to ethanol and diazepam via GABAA receptor signaling
Pharmacological profile of S 76892, a new ligand at nicotinic α7-subtype receptors
Importance of microglial α7 nicotinic receptors in neuroprotection: The central cholinergic anti-inflammatory pathway
The β2 subunit C loop of the nicotinic acetylcholine receptor directs allosteric modulator specificity
The influence of VTA GABAergic interneurons on β2-containing nAChR-mediated dopamine neuron activity at baseline and during nicotine application: A modeling study
Nicotinic receptor excitation of descending pain modulatory pathways
Cembranoids structure–activity relationship for protection against diisopropylfluorophosphate damage
Structural studies of nicotinic acetylcholine receptor α1 subunit and Fab35 complex to understand autoimmune disease of myasthenia gravis
Engineered acetylcholine binding proteins to explore ligand recognition and specificity
A survey of high resolution AChBP X-ray structures reveals details of tertiary and quaternary movements of the protein, both real and imagined, upon ligand binding
Nocturnal frontal lobe epilepsy-associated intracellular-loop mutant subunits alter single-channel properties of α4β2-nicotinic receptor isoforms
Differential modulation of α3β4 and α3β4α5 nAChR isoforms by the endogenous neuromodulator lynx1
Radiosynthesis and in vitro validation of [3H]NS14492 as a novel high affinity α7 nicotinic receptor radioligand
Antidyskinetic effect of the novel α7 nicotinic receptor agonist ABT-126 in parkinsonian monkeys
Striatal cholinergic interneurons regulate L-dopa-induced dyskinesias
Nicotinic regulation of central auditory processing: Towards a drug therapy for auditory processing disorders
The deletion of the α7 subunit partially rescues vestibular dysfunction in the α9 knockout
Auditory sensory gating and inflammation as translational biomarkers of α7 nicotinic acetylcholine receptor agonists in the treatment of neuropsychiatric disorders
Nicotinic receptors increase cell proliferation and tumour progression in non-small cell lung cancer cell line
Nicotinic modulation of auditory evoked potential electroencephalography in a rodent neurodevelopmental model of schizophrenia
The nicotinic receptor modulator, lynx2, controls anxiety via regulation of the cholinergic system
Reduction of aggressive behavior in mouse models by the selective α7 nicotinic partial agonist GTS-21
Activation of the kappa-opioid receptor system is both necessary and sufficient for reinstatement of nicotine place preference
Diverse nicotinic mechanisms in a model of multiple sclerosis
Imaging CA1-hippocampal neuronal ensembles during nicotine-dependent contextual associations
The role of the dynorphin-kappa-opioid system in reinstatement of nicotine-seeking in mouse self-administration
α5 nAChR modulation of the effects of nicotine on ventral-striatal DA release and cue-reward learning
Nicotinic treatments not only for tobacco, but also other addictions
Positive allosteric modulation of the α7 nicotinic acetylcholine receptor reverses chronic cognitive deficits after TBI
APN1125: A clinical stage α7 nicotinic acetylcholine receptor partial agonist
APN0417: A potent and efficacious α7 nAChR positive allosteric modulator