Joint ICMAN and IUPHAR natural products section meeting. Aberdeen UK 27-29th September 2017
Sponging off nature for new drug leads
Factors modulating bioavailability of quercetin-related flavonoids and the consequences of their vascular function
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Natural product-based amyloid inhibitors
Cancer combination therapies with artemisinin-type drugs
Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action
The gut microbiota: A key factor in the therapeutic effects of (poly)phenols
Major achievements of evidence-based traditional Chinese medicine in treating major diseases
Sponging off nature for new drug leads : I1
Nutraceuticals retrieved from food processing waste : I2
Factors affecting bioavailability of plant polyphenols : I4
Bioavailability and anti-diabetic action of naturally-occurring flavonoids and phenolic acids : I5
Natural product-based protein amyloid inhibitors : I6
Marine natural products as starting points for drug discovery and development : I8
IUPHAR: Immunology, metabolism and natural products : I9
The anticancer activity of the antimalarial artesunate : I10
Personalised nutrition, nutraceuticals and multi-omic diagnostics to precisely prevent ageing at the fundamental genome level and optimise tissue regeneration : I11
Repositioning andrographolide for airway inflammation: Mapping its mechanistic networks : I12
West meets east: A systems biology approach to the mechanistic understanding of traditional medicines : I14
Nootropic effect and action mechanisms of Ginsenoside Rg1, a smart drug candidate : I15
Salvianolic acid A, a natural product obtained from Salvia miltiorrhiza alleviates diabetic complications : I16
Interaction of polyphenols with gut microbiota; understanding the health effects of polyphenols : I7
Cancer chemopreventive effects of natural products with anti-inflammatory and pro-resolving activities : I18
Major achievements of traditional medicine in treating epidemic and chronic diseases : I19
Isolation and identification of an antimicrobial and cytotoxic chlorated perylenequinone from the symbiotic fungus Aspergillus fumigatus D : O1
An in vitro study on the anti-cancer properties of rapeseed pomace extracts : O3
Nature Open Library, an Open Innovation initiative to boost the exploration of natural products : O5
Proteome, biochemical and plasma glucose analysis of Coscinium fenestratum stem extract as an anti-diabetic agent : O7
Study on antihypertensive activity of an aqueous extract of Anogeissus leiocarpus (AEAL) DC Guill et Perr bark of trunk in L-NAME-induced hypertensive rats : O8
Isolation, identification and anti-cancer activity of minor alkaloids from Triclisia subcordata Oliv : O9
Beneficial effect of Phyllanthus amarus (Euphorbiaceae) on DOCA-salt-induced left ventricle cardiac hypertrophy and endothelial dysfunction in rats : O10
Endothelium-dependent relaxation by a hydroethanolic extract of Adansonia digitata leaves in porcine coronary artery rings and rat thoracic aorta, mesenteric, carotid artery rings: Role of NO and EDH : O11
Effect of the hexane fraction obtained from the hydroalcoholic extract of Punica granatum leaves on cecal ligation and puncture-induced sepsis in mice : O12
Quantitative analysis of an oil based natural compound extracted from plasma : O13
Determination of DQ-798 in rat plasma by UHPLC-MS/MS and its application to a pharmacokinetic study : O14
Bioaccessibility of organosulphur compounds from Allium sativum : O15
Phyto-oestrogenic property of mimosine: A phenylalanine alkaloid : O16
Identification and characterisation of phytochemicals activating endogenous cytoprotective mechanisms : O17
Revalorisation of rapeseed pomace (RSP): A study into antioxidant and DNA protective properties ( in vitro ) of a RSP extract and its effects on neurodegenerative disease C. elegans models : O18
Ganoderma triterpenes inhibit kidney cyst development via down-regulating the Ras/MAPK signaling pathway : O19
Low molecular weight fucoidan inhibits fibrotic processes in diabetic nephropathy : O20
Protective effect of Anogeissus acuminata bark extract against experimentally induced diabetic neuropathy in Wistar rats : O21
The key role of analytical sciences in the discovery and characterization of bioactives from food and nutraceuticals : O22
Drug development with natural products – A journey : O23
Functionality of selected seaweed extracts on selected pharmaceutical applications : O24
A novel synthetic ω-3 fatty acid epoxide analogue activates breast cancer cell killing in vitro and in vivo : O25
Screening active components of Modified Xiaoyao Powder for chemoprevention in breast cancer cells: Involvement of the NRF2/NQO1 signalling pathway : O26
Chemopreventive activities of kolaviron, a novel bioflavonoid from the seed of Garcinia kola : Mechanistic perspectives : O27
Importance of pro-inflammatory immune lymphocyte Th17 in antitumoral properties of resveratrol, a polyphenol of wine : O28
Nrf2/HO-1 pathway alleviates epithelial-mesenchymal transition by inhibiting HMGB1 expression in pulmonary fibrosis : O29
Natural compounds affecting neutrophil migration : O30
Can colonic metabolites be responsible for the hypotensive effect of orally given quercetin? : O31
Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in normal gastric mucosa RGM-1 cells and mouse stomach in vivo : A potential role of AP-1 : O32
Oxidative stress induced both apoptosis and necroptosis in endothelial cells : O33
Endothelium-independent vasorelaxant effect of Thymus linearis via inhibition of phosphodiesterases in porcine coronary artery : O34
An anthocyanin-rich blackcurrant extract induced NO-mediated relaxation in coronary artery rings and eNOS phosphorylation in cultured endothelial cells: Role of sodium-glucose cotransporters 1 and 2 : O35
Endothelium-dependent contractions depending on biased sGC activation: The Janus face of thymoquinone : O36
Salidroside prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation : O37
The omega-3 EPA:DHA 6:1 formulation improves ageing-related blunted endothelium-dependent relaxations and increased contractile responses in the mesenteric artery: Role of oxidative stress and cyclooxygenases : O38
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity : O39
The omega-3 EPA:DHA 6:1 formulation prevents the monocrotaline-induced pulmonary hypertension, pulmonary artery remodelling, endothelial dysfunction, and right ventricular failure in rats : O40
Traditional Chinese medicine Liuwei Dihuang decoction and its new formula, LW-AFC, as promising therapies against Alzheimer’s disease: Pharmacological actions and mechanisms : O41
MAM, a natural naphthoquinone, induces necroptosis in cancer cells : O42
The effects and mechanisms of two main constituents from Glycyrrhiza uralensis Fisch-induced autophagy in non-small cell lung cancer : O43
Nutritional protection against obesity : O44
Validation study of a food frequency questionnaire for the measurement of food consumption in polyphenols: Use of a urinary biomarker. Preliminary results : O45
Selenium supplementation and modified high-intensity interval training (m-HIIT) to modulate systemic oxidative stress in sedentary overweight/obese adults: In vitro and in vivo studies : O46
Antiproliferative and apoptosis induction of methanolic extract from Muntingia calabura L leaves on WiDr colorectal cancer cell line : P1
Exploring the functional components of the African horned cucumber ( Cucumis metuliferus ), Mokapana (Tswana) – Characterisation by phenolic content and antioxidant activity in Botswana : P2
Trichilia monadelpha (TM) Thonn J.J. de Wilde ameliorates oxidative stress and inflammation in TNBS-induced colitis : P3
Diallyl Trisulfides, a garlic-derived organosulfur compound, attenuates vascular metastasis of hypoxic breast cancer cells by targeting the thioredoxin system : P4
Histological and antihyperlipidemic screening along with plasma uric acid reducing potential of ethanolic extract of Momordica charantia seeds on swiss albino mice model : P5
Herbs for Health: An alternative approach to identify newer therapeutic option for the treatment of diabetes : P6
Extract of Ligusticum chuanxiong Hort attenuates LPS-induced neuroinflammation in BV2 microglia via down-regulation of TLR4/MyD88 pathway : P7
Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ : P8
The effect of ethanolic extract of red betel vine leaves ( Piper crocatum ) to the livers and kidneys of DDY mice in acute and subchronic toxicity study : P9
Effects of Sanseviera liberica methanolic root extract on liver glycogen and serum insulin in streptozotocin-induced diabetic albino rats : P10
Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines : P11
An anti-tumor natural product boswellic acid acetate (BC-4) from Boswellia carterii Birdw : P12
Pinocembrin isolated from Propolis induces relaxation of rat basilar artery rings through both endothelium-dependent and -independent pathways : P13
LW-AFC treatment improves learning-memory ability and brain glucose metabolism in a mouse model of Alzheimer’s Disease : P14
Effects of coptisine on glucose metabolism and the mechanisms : P15
Network pharmacology studies on the effective constituents from the Compound Yizhihao against influenza : P16
Identification of a novel synergistic combination of natural extracts for infection control in diabetic ulcers : P17
High-sensitivity and rapid UPLC-MSn assay effective components in Radix salviae miltiorrhizae in rat brain microdialysate : P18
Intracerebral microdialysis studies on the role of Pinocembrin on CYP3A in rat : P19
The novel compound HLY effectively relieves ulcerative colitis by xbp1-myh9 pathway : P20
Antioxidant activity of the extract of Lingzhi mushroom ( Ganoderma lucidum ): As reductant and inhibitor of lipid peroxidation : P21
Discovery of new bioactive compounds from ( Dioclea reflexa Hook F.): Effective constituents of a traditional herbal medicine : P22
Saikosaponin a ameliorate learning and memory impairment via anti-inflammation effect in an AD mouse model : P23
Matrine ameliorates cognitive deficits and neuroinflammation via inhibition of microglial activation in an Alzheimer’s disease mouse model : P24
Trichodimerol induces apoptosis in A375-S2 human melanoma cells through modulation of ERK and p38 activities mediated by reactive oxygen species : P25
Tamaractam, a natural lactam, induces apoptosis and inhibits inflammation in rheumatoid arthritis fibroblast-like synoviocytes : P26
Minimising the toxic effects of beta-Amyloid 42 on oxidative stress : P27
Nrf2 antioxidant pathway suppresses epithelial-mesenchymal transition through up-regulating Numb during pulmonary fibrosis : P28
The in vitro use of natural antioxidant oils (Cyperus esculentus; Nigella sativa) to reduce cell sickling in sickle cell anaemia : P29
GC–MS analysis and pharmacological activity study of the essential oil from Allium cepa : P30
Role of sesquiterpene lactones against human ovarian cancer : P31
The effects of Magnolia poasana extracts on vascular function and platelet aggregation – A comparison with magnolol : P32
Inorganic nanostructures for hydrophobic anticancer drug delivery : P33
Efficient assessment of a six-probe cocktail for CYPs following intravenous microdosing for pharmacokinetic studies : P34
The anti-inflammatory effect of silymarin in chondrocytes : P35
Proteomics studies on effect of Xiao-Xu-Ming decoction on cerebral ischemia rat by UPLC-Q-Exactive technology : P36
Sulforaphane modulates joint inflammation in mouse CFA-induced mono-arthritis : P37
Immunoregulatory effects and mechanisms of four Milk-borne probiotics in immunocompromised Balb/c mice : P38
Effects of metabolic modifications of green tea catechins on their ADME/Tox properties including binding to human serum albumin : P39
Alchornea cordifolia Leaf-Extracts Confer Protection from DNA Damage and Reactive Oxygen Species (ROS) : P40
Microwave-assisted extraction and HPLC analysis of polyphenols from pitaya peel and its inhibitory effect on human lung cancer cell line A549 : P41
Chemical analysis and pharmacodynamic study of Wollea saccata biopolymer effect on respiratory system : P42
The Isolation and Purification of Bioactive Metabolites from Ficus carica and Their Neuroprotective Effects in Alzheimer’s Disease : P43
Carboxymethyl-glucan extracted from Saccharomyces cerevisiae induces vasodilation mediated by the NOS/NO/SCG pathway and negative inotropic effects in rats : P44
Hydroalcoholic extracts of Syzygium cumini (L.) Skeels fruit peel reduces weight gain and improves oxidative stress and vascular response in rats fed a hypercaloric diet : P45
Acaí pulp (Euterpe oleraceae Martius) consumption improves lipidic peroxidation markers in healthy women : P46