DNA methylation with a sting: an active DNA methylation system in the honeybee

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Abstract

Summary

The existence of DNA methylation in insects has been a controversial subject over a long period of time. The recently completed genome sequence of the honeybeeApis melliferahas revealed the first insect with a full complement of DNA methyItransferases.(1) A parallel study demonstrated that these enzymes are catalytically active and thatApisgenes can be methylated in specific patterns.(2) These findings establish bees as a model to analyze the function of DNA methylation systems in invertebrate organisms and might also be important to understand evolutionary aspects of DNA methylation in higher eukaryotes.BioEssays29:208–211, 2007.

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