Our understanding of genomic reorganization, the mechanics of genomic transmission to offspring during germ line formation, and how these structural changes contribute to the speciation process, and genetic disease is far from complete. Earlier attempts to understand the mechanism(s) and constraints that govern genome remodeling suffered from being too narrowly focused, and failed to provide a unified and encompassing view of how genomes are organized and regulated inside cells. Here, we propose a new multidisciplinaryIntegrative Breakage Modelfor the study of genome evolution. The analysis of the high-level structural organization of genomes (nucleome), together with the functional constrains that accompany genome reshuffling, provide insights into the origin and plasticity of genome organization that may assist with the detection and isolation of therapeutic targets for the treatment of complex human disorders.
Our understanding of genome reorganization and how these structural changes contribute to the speciation process and genetic disease is far from complete. In this report we propose a new multidisciplinary Integrative Breakage Model of genome evolution that is based on the high-level structural organization of genome (nucleome) and highlight the functional constrains that lead to genome reshuffling.