caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens

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Abstract

Motivation: Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing.

Results: The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports.

Availability and implementation: caRpools, manuals and an open virtual appliance are available at http://github.com/boutroslab/caRpools.

Contact:m.boutros@dkfz.de

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