TreeQTL: hierarchical error control for eQTL findings

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Abstract

Summary: Commonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a hierarchical multiple testing procedure which allows control of appropriate error rates defined relative to a grouping of the eQTL hypotheses.

Availability and Implementation: The R package TreeQTL is available for download at http://bioinformatics.org/treeqtl.

Contact:sabatti@stanford.edu

Supplementary information: Supplementary data are available at Bioinformatics online.

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