Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment

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The concept of a ‘mechanism-based taxonomy of human disease’ is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.


We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a ‘mechanism-enrichment server’ that supports the mechanistic interpretation of multiscale, multimodal clinical data.

Availability and implementation

NeuroMMSig is available at


Supplementary information

Supplementary data are available at Bioinformatics online.

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