PREFMD: a web server for protein structure refinement via molecular dynamics simulations

    loading  Checking for direct PDF access through Ovid


Summary:Refinement of protein structure models is a long-standing problem in structural bioinformatics. Molecular dynamics-based methods have emerged as an avenue to achieve consistent refinement. The PREFMD web server implements an optimized protocol based on the method successfully tested in CASP11. Validation with recent CASP refinement targets shows consistent and more significant improvement in global structure accuracy over other state-of-the-art servers.Availability and implementation:PREFMD is freely available as a web server at Scripts for running PREFMD as a stand-alone package are available at information:Supplementary data are available at Bioinformatics online.

    loading  Loading Related Articles