1CAS Key Laboratory of Genome Sciences and Information, Chinese Academy of Sciences, Beijing, China2BIG Data Center (BIGD), Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China3University of Chinese Academy of Sciences, Beijing, China
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SummaryDelta is an integrative visualization and analysis platform to facilitate visually annotating and exploring the 3D physical architecture of genomes. Delta takes Hi-C or ChIA-PET contact matrix as input and predicts the topologically associating domains and chromatin loops in the genome. It then generates a physical 3D model which represents the plausible consensus 3D structure of the genome. Delta features a highly interactive visualization tool which enhances the integration of genome topology/physical structure with extensive genome annotation by juxtaposing the 3D model with diverse genomic assay outputs. Finally, by visually comparing the 3D model of the β-globin gene locus and its annotation, we speculated a plausible transitory interaction pattern in the locus. Experimental evidence was found to support this speculation by literature survey. This served as an example of intuitive hypothesis testing with the help of Delta.Availability and implementationDelta is freely accessible from http://delta.big.ac.cn, and the source code is available at https://github.com/zhangzhwlab/delta.Supplementary informationSupplementary data are available at Bioinformatics online.