Multiple imputation methods for testing treatment differences in survival distributions with missing cause of failure

    loading  Checking for direct PDF access through Ovid


SUMMARYWe propose a method for comparing survival distributions when cause-of-failure information is missing for some individuals. We use multiple imputation to impute missing causes of failure, where the probability that a missing cause is that of interest may depend on auxiliary covariates, and combine log-rank statistics computed from several ‘completed’ datasets into a test statistic that achieves asymptotically the nominal level. Simulations demonstrate the relevance of the theory in finite samples.

    loading  Loading Related Articles