Production of octadecylphospho-l-serine by phospholipase d

    loading  Checking for direct PDF access through Ovid


Octadecylphospho-l-serine (OPS), belonging to the family of alkylphosphate esters with anticancer activity, was synthesized by transesterification of octadecylphosphocholine using phospholipase d (PLD). With respect to the yield of product, PLD from cabbage proved to be superior to PLD from Streptomyces spp. Although the addition of n-hexane/2-octanol is advantageous to suppress the hydrolytic byproduct, a purely aqueous reaction medium was preferred because of better recovery of the product.

Related Topics

    loading  Loading Related Articles