Molecular Exchange of Metal Ions and Tissular Calcium Overload

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In vitro and in vivo, mouse tissues assayed for 45Ca2+ uptake have shown that ATP increases the Ca2+ take-up in the presence of lactates of iron and aluminum, but this effect is absent with the citrates. The in vitro metal ion exchange with ATP has been demonstrated by electrophoresis and by chromatography. It is considered the cause of the increased capacity of ATP to modify the cellular effects of lactates. The in vitro modifications of Ca2+ uptake by lactates when in the presence of ATP are much more important than those of citrate. In general, aluminum compounds show a higher Ca2+ uptake and, coincidentally, they have shown a higher carcinogenic capacity than iron ATP.

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