Comparative study of photodynamic therapy vs. CO2 laser vaporization in treatment of condylomata acuminata, a randomized clinical trial

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Most conventional therapies for condylomata acuminata (CA) are traumatic and have high recurrence rates.

Objectives

To investigate the efficacy and safety of topical application of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of CA.

Methods

Sixty-five patients with CA were allocated into the treatment (ALA-PDT) group and treated with 20% ALA solution under occlusive dressing for 3 h followed by irradiation with the helium–neon laser at a dose of 100 J cm−2 and a power of 100 mW. Another 21 CA patients were allocated into the control group and treated with the CO2 laser. The treatment was to be repeated 1 week later if the lesion was not completely removed after the first treatment.

Results

After one treatment, the complete removal rate was 95% in the ALA-PDT group and 100% in the control group. After two treatments with ALA-PDT, the complete removal rate in the treatment group was 100%. The recurrence rate for ALA-PDT group was 6·3% which was significantly lower than that in control group (19·1%, P < 0·05). Moreover, the proportion of patients with adverse effects in the ALA-PDT group (13·9%) was also significantly lower than that in control group (100%, P < 0·05). The side-effects in patients treated with ALA-PDT mainly included mild burning and/or stinging restricted to the illuminated area.

Conclusions

The present study shows that topical application of ALA-PDT is a simpler, more effective and safer therapy with a lower recurrence for treatment of CA compared with conventional CO2 laser therapy.

Related Topics

    loading  Loading Related Articles