Vitamin D deficiency in alopecia areata*

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SummaryBackgroundAlopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-stage hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases. Previous reports have described the effects of vitamin D on hair follicles.ObjectivesTo evaluate the status of vitamin D in patients with AA, and the relationship between vitamin D levels and disease severity.MethodsA cross-sectional study of 86 patients with AA, 44 patients with vitiligo and 58 healthy controls was conducted. The serum vitamin D levels of the study group were determined by liquid chromatography/tandem mass spectrometry.ResultsSerum 25-hydroxyvitamin D [25(OH)D] levels in patients with AA were significantly lower than those of the patients with vitiligo and the healthy controls (P = 0·001 and P < 0·001, respectively). The prevalence of 25(OH)D deficiency was significantly higher in patients with AA (91%) compared with patients with vitiligo (71%) and healthy controls (33%) (P = 0·003 and P < 0·001, respectively). Furthermore, a significant inverse correlation was found between disease severity and serum 25(OH)D level in patients with AA (r = −0·409; P < 0·001).ConclusionsDeficient serum 25(OH)D levels are present in patients with AA and inversely correlate with disease severity. Accordingly, screening patients with AA for vitamin D deficiencies seems to be of value for the possibility of supplementing these patients with vitamin D.What's already known about this topic?Alopecia areata (AA) is considered to be a T cell-mediated autoimmune disease characterized by patchy loss of hair from the scalp and other body parts.Vitamin D deficiency has been implicated in different autoimmune disorders.What does this study add?Deficient serum vitamin D levels are present in patients with AA and are inversely correlated with disease severity.

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