Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study

    loading  Checking for direct PDF access through Ovid

Abstract

Background

Epidermal barrier impairment and an altered immune system in atopic dermatitis (AD) may predispose to ultraviolet-induced DNA damage.

Objectives

To study the association between AD and actinic keratosis (AK) in a population-based cross-sectional study.

Methods

AD was defined by modified criteria of the U.K. working party's diagnostic criteria. AKs were diagnosed by physicians during a full-body skin examination, and keratinocyte cancers were identified via linkage to the national pathology database. The results were analysed in adjusted multivariable and multinomial models.

Results

A lower proportion of subjects with AD had AKs than those without AD: 16% vs. 24%, P = 0·002; unadjusted odds ratio (OR) 0·60, 95% confidence interval (CI) 0·42–0·83; adjusted OR 0·74, 95% CI 0·51–1·05; fully adjusted OR 0·69, 95% CI 0·47–1·07. In a multinomial model patients with AD were less likely to have ≥ 10 AKs (adjusted OR 0·28, 95% CI 0·09–0·90). No effect of AD on basal cell carcinoma or squamous cell carcinoma was found: adjusted OR 0·71, 95% CI 0·41–1·24 and adjusted OR 1·54, 95% CI 0·66–3·62, respectively.

Conclusions

AD in community-dwelling patients is not associated with AK.

Related Topics

    loading  Loading Related Articles