CD3- CD4- CD8- CD56- CD19- CD14- cells and CD3+ CD8 dull-positive cells produce IL-4 in AIDS patients

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Abstract

Summary

We used flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse the production of IL-4 in peripheral blood from AIDS patients who have practically no CD4+ T cells. We found that IL-4 was produced by CD3- CD4- CD8- CD56 (-) CD19- CD14- cells and CD3+ CD8 dull-positive cells in AIDS patients. Moreover, CD3- CD4- CD8- CD56- CD19- CD14- cells had helper activity for immunoglobulin synthesis. These findings indicate that instead of CD4+ T helper cells, C3- CD4- CD8- CD56- CD19- CD14- cells and CD3+ CD8 dull-positive cells may be an important source of IL-4 in a variety of immune responses for AIDS patients.

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