Increased serum phosphodiesterase activity in women with pre-eclampsia

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Abstract

Objective

To measure the activity of serum phosphodiesterase (PDE) in pre-eclampsia.

Design

Case–control study.

Setting

Nephrology Laboratory and Obstetrics Unit at São Lucas Hospital from Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

Sample

Twenty-nine normal and 28 pregnant women with pre-eclampsia.

Methods

Serum was collected from women with pre-eclampsia, at the time of diagnosis, and from gestation-matched controls. Circulating PDE activity was assessed by measuring consumption of the substrate thymidine 5′-monophosphate p-nitrophenyl ester and expressed as PDE units/l.

Main outcome measures

Serum PDE Activity.

Results

Mean substrate consumption was higher in pre-eclamptic condition (Vmax= 15.8 ± 1.4 versus 12.7 ± 0.9 U/L, P= 3.7 × 10−14).

Conclusion

These data suggest that altered PDE activity may play a role in pre-eclampsia endothelial dysfunction.

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