Impact of pre-admission depression on mortality following myocardial infarction

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The prognostic impact of previous depression on myocardial infarction survival remains poorly understood.


To examine the association between depression and all-cause mortality following myocardial infarction.


Using Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995–2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.


We identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07–1.15) increasing to 1.22 (95% CI 1.17–1.27) when including use of antidepressants in the depression definition.


A history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.

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