Histamine in human breast cancer

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Background:Histamine inhibits lymphocyte function in vitro at concentrations of greater than 10-6 mol/l. The aim of this study was to determine whether histamine concentrations in breast cancers were sufficient to produce an immunological effect.Methods:Tumour and adjacent normal breast content of histamine was measured using a radioenzymatic assay in 29 patients having surgery for breast cancer.Results:The median content of histamine in breast cancer tissue was 5.4 (range 0.9-27.3) [micro sign]g/g (median concentration 4.5 x 10-5 mol/l), and was significantly greater than that in adjacent breast tissue (P = 0.007).Conclusion:The concentration of histamine in breast cancer was sufficient to inhibit lymphocyte function and could be locally immunosuppressive.

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