Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase Iin vivohuman study

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Abstract

What's known on the subject? and What does the study add?

Optical Coherence Tomography (OCT) was deloped in the early 1990s for ophthalmological application and is currently widely accepted in ophthalmology for retinal imaging purposes. Inkidneys, the first experiments were performed on transplant kidneys to investigate the ability of OCT to assess ischaemic damage of kidneys. An ex vivo pilot study on the ability of OCT to differentiate normal renal tissue from alignant renal tissue, showed positive results and here we present the results of the first in vivo experiment.

The studyshows for the first time that in vivo OCT is feasible and safe to perform in humans and that a significant diffnt attenuation coefficient (as a quantitative measurement of the OCT images) is found between normal renal tissue and malignant renal tumours with a clear trend towards significance in the difference between benign and malignant renal tumours in a small pilot study. This suggests potential use of OCT in different clinical settings for diagnostic purposes in the course of renal tumours, and justifies further research.

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