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Percutaneous treatment for renal stone disease is associated with a risk of significant morbidity.Our large UK series provides contemporary data on the risk of vascular complications and admission to the Intensive Care Unit (ICU) after PCNL. When compared with recent international databases, these data support the current evidence that better outcomes can be achieved in centres performing large numbers of procedures. These data add to the debate for the centralisation of specialist stone surgery.To audit the outcome of percutaneous nephrolithotomy (PCNL) at a UK stone centre over a 10-year period, and provide patients with understandable contemporary data on blood loss and vascular risk.A single centre retrospective analysis of all PCNLs undertaken between April 2000 and December 2010.The association between transfusion and patient age, operative duration and positive preoperative mid-stream urine (MSU) sample was subject to statistical analysis.Data on 568 patients was analysed. 21 were paediatric cases with a mean (range) age of 8 (2–16) years; 547 were adult cases with a mean (range) age of 55 (17–84) years.3.8% of adult patients (21/547) received a blood transfusion; mean age 60 years (55 years in those not transfused) with a mean operative duration of 119 min (103 min in those not transfused).23.8% of patients transfused had a confirmed preoperative urinary tract infection compared with 16.1% of those not transfused.Seven patients underwent angiography, with five having selective arterial embolisation (0.9%).There were no deaths in this series although one patient (0.2%) required an urgent nephrectomy due to cardiovascular instability from bleeding.Large UK series that provides contemporary data for consent on vascular risk at PCNL.The risk of transfusion is associated with increased patient age, operative duration and the presence of a positive preoperative MSU sample.Data compares favourably with other large published series, and supports the argument for centralisation of percutaneous stone management.