Human uterus transplantation in focus

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Uterus transplantation (UTx) is introduced as the first treatment for absolute uterine factor infertility (AUFI), affecting 1:500 fertile aged women. This review presents potential patients, research and human UTx cases.

Sources of data

Published articles and our research experience.

Areas of agreement

The first UTx live births in 2014 established UTx as a possible treatment for AUFI. This was proceeded by 15 years of systematic research.

Areas of controversy

Is a deceased donor UTx as effective as the proven successful live donor UTx?.

Growing points

Human UTx trials will accumulate data on risks, effectiveness and long-term consequences for donors, recipients and children. These should also include aspects of quality of life, psychological well-being and cognitive/neuropsychiatric development of children.

Areas timely for developing research

All new activities in human UTx within the coming years should be conducted as prospective observational studies, and data should also be collected within an international registry.

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