The associations between high-density lipoprotein mean particle size and its fatty acid composition

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High-density lipoprotein (HDL) particles are heterogeneous in their composition, structure and size and may differ in conferring protection against coronary artery disease. The aim of this study is to investigate the associations between HDL size and its fatty acid composition.

Patients & methods:

HDL mean particle size from 140 healthy men was detected by dynamic light scattering methodology and fatty acid composition of HDL was determined by gas chromatography.


HDL with smaller size had a higher proportion of saturated fatty acids and lower proportion of unsaturated fatty acids. HDL mean size indicated a negative correlation with palmitic acid (r = -0.17; p < 0.05) and a positive correlation with palmitoleic acid (r = 0.17; p < 0.05), oleic acid (r = 0.23; p < 0.01), arachidonic acid (r = 0.17; p < 0.05) and dihomogamalinoleic acid (r = -0.18; p < 0.05).


Saturated fatty acids of HDL are inversely assocaited and unsaturated fatty acids are directly associated with HDL mean size.

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