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Although present evidence does not indicate any relationship between multiple myeloma and Paget's disease of bone, the authors feel that multiple myeloma should be ruled out, by marrow aspiration or biopsy, in those cases of Paget's disease with welldefined areas of decalcification and no adjacent sclerosis.In the case presented, treatment with stilbamidine (a total of 2.85 grams) caused early disappearance of all pain and increased spinal mobility. Basophilic granules, which had not been present prior to therapy, appeared in the cytoplasm of the myeloma cells. The patient experienced no serious or permanent ill effects attributable to therapy. The transitory ill effects accompanying the administration of stilbamidine can be avoided by certain simple precautions.