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1. Ten cases of arthrodesis of the knee in nine patients for neuropathic joint disease have been presented. One patient died soon after the arthrodesis. Another patient had a bilateral arthrodesis. All of the eight patients (nine knees) available to follow-up showed successful arthrodesis.2. The degenerated and hypertrophied synovium has been indicated as a significant factor in preventing successful arthrodesis of the neuropathic knee. Evidence in support of this contention is presented.3. The rate of fusion of the Charcot knee will improve if adequate bone resection, complete synovectomy, and firm internal fixation are combined with early diagnosis and adequate postoperative care.