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Neuronal intranuclear rodlets were described in normal brain over a century ago, but their functional significance and pathological relevance is unknown. Here, we show co-localization of tubulin and glucocorticoid receptor-like immunoreactivity in these intranuclear inclusions in human brain. In addition, we provide evidence for a massive reduction in their areal density in Alzheimer’s disease brain, but not in another common neurodegenerative condition, dementia with Lewy bodies. The marked reduction of these inclusions in Alzheimer’s disease may support the concept of a role for stress hormones in Alzheimer’s pathogenesis.