Why does spironolactone improve mortality over and above an ACE inhibitor in chronic heart failure?
Integrated modelling of the clinical pharmacokinetics of SDZ HTF 919, a novel selective 5-HT4 receptor agonist, following oral and intravenous administration
Combination of calcium channel blockers and β-adrenoceptor blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers
Nisoldipine improves the impaired erythrocyte deformability correlating with elevated intracellular free calcium-ion concentration and poor glycaemic control in NIDDM
Impaired cholinergic dilator response of resistance arteries isolated from patients with Raynaud's disease
Study of cardiac repolarization in healthy volunteers performed with mizolastine, a new H1-receptor antagonist
Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers
Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers
Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil
The influence of CYP2D6 activity on the kinetics of propafenone enantiomers in Chinese subjects
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke
Drug reactions to cotrimoxazole in HIV infection: possibly not due to the hydroxylamine metabolites of sulphamethoxazole
Transplacental distribution of labetalol stereoisomers at delivery
Passive smoking increases arterial stiffness in healthy subjects
The haemodynamic effects of systemic endothelin A receptor antagonism in healthy humans in vivo
Platelet adenylyl cyclase signalling in children undergoing haemodialysis treatment
In vivo indices of enzyme activity: the effect of renal impairment on the assessment of CYP2D6 activity
Fraction of dose of drug converted to a metabolite when both compete for metabolism by the same enzyme
Glucuronylation of α-hydroxytamoxifen: a deactivation pathway in humans?
Altered caffeine metabolism in patients with Parkinson's disease
Factors affecting the acceptance of drug therapy to prevent myocardial infarction
Effect of the Committee on Safety in Medicines (CSM) warning on contraceptive use in the general medical services (GMS) in Ireland
The origin of errors in dosage: acetylcysteine as a paradigm
Alcohol and illicit drug use in medical students and junior doctors at Newcastle University: a longitudinal study
Effect of pentagastrin on the pupil and cardiovascular functions in healthy volunteers
Assessment of the relationship between analgesia and plasma concentrations of dihydrocodeine and dihydromorphine following dihydrocodeine administration
Safety and pharmacodynamics of single ascending doses of SL34.0026, a new reversible and selective MAO-B inhibitor in healthy subjects
Effect of racemic and (R)- and (S)-warfarin on carboxylase activity and the vitamin K cycle
Reduced vascular stiffness by angiotensin II receptor blockade in uncontrolled hypertension
Cytochrome P450 2D6 (CYP2D6) activity in relation to the antitussive effect of dextromethorphan
The paraxanthine/caffeine ratio in saliva as a marker of CYP1A2 activity
Drug interaction studies and metabolic enzyme characterisation with zolmitriptan ('Zomig')
A possible role for metabolism in modulating the oestrogenic activity of xenoestrogens measured by the rodent uterotrophic assay
Predicting cyclosporin area under the concentration-time curve is better achieved using artificial neural networks than linear regression
Pharmacokinetics of milameline in patients with impaired liver function
Inhibition of debrisoquine hydroxylation by tramadol
The effects of acute ethanol intake on isoniazid pharmacokinetics
Hashimoto's thyroiditis and acetylator status: a comparison of genotype and phenotype
The effect of grapefruit juice constituents on the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of saquinavir
The effect of P-glycoprotein on saquinavir absorption in Caco-2 cells
Role of cytoskeleton and effect of ageing in transmembrane receptor adenylate cyclase signalling in human platelets
Drug interactions avoided: an index of good prescribing practice
Poor documentation of drug hypersensitivity in hospital records
Pharmacogenetics of thiopurine methyltransferase: genotype vs phenotype
Randomized trial of step-3 diet vs simvastatin therapy for reduction in risk of coronary heart disease
Effect of diltiazem on the cholesterol-lowering response to simvastatin: a CYP3A4-mediated reaction
Effect on ACE inhibitor cough of replacing the ACE inhibitor with losartan
Effect of delayed activated charcoal administration on paracetamol absorption after simulated overdose
Simulated driving in light and dark conditions: elderly subjects, alcohol and diazepam
Job satisfaction and stress in pre-registration house officers in the north east of England
Actigraphy: a useful tool for studying sleep and behavioural problems in older people in their own environment
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