Features of this month's Journal
The British Journal of Clinical Pharmacology Editors' Report for 2002
Quality, efficacy and safety of complementary medicines
Bronchodilator effects of intravenous olprinone, a phosphodiesterase 3 inhibitor, with and without aminophylline in asthmatic patients
Influence of captopril on symptomatic and hormonal responses to hypoglycaemia in humans
An evaluation of short-term corticosteroid response in perennial allergic rhinitis using histamine and adenosine monophosphate nasal challenge
Pharmacokinetics of ribavirin in combined interferon-alpha 2b and ribavirin therapy for chronic hepatitis C virus infection
The pharmacokinetics of pioglitazone in patients with impaired renal function
Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease
Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam
Undertreatment of hypercholesterolaemia
Valproate overdose
A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg
A life-threatening interaction between lithium and celecoxib
Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population
Antiepileptic drug hypersensitivity syndrome in a patient treated with valproate
Antibiotic prescribing to children in general practice
Determining values for human microsomal protein per gram of liver
Have COX 2 inhibitors influenced the co-prescription of anti-ulcer drugs with NSAIDs?
The activities of CYPs 3A4, 2D6 and 1A2 in methadone maintenance patients
Sex differences in QTc interval in patients prescribed amiodarone
Abacavir hypersensitivity in human immunodeficiency virus-positive patients
The Declaration of Helsinki's international guidelines for research ethics
Plasma salicylate concentrations following overdose
Treatment of yellow oleander poisoning with multiple dose activated charcoal
Effects of glyceryl trinitrate and amyl nitrite on pulse wave reflection and augmentation index
The effects of L-arginine on arterial stiffness and haemodynamic parameters in hypercholesterolaemics and normal controls
The effects of acute caffeine administration on central arterial blood pressure
Spironolactone reduces arterial stiffness in hypertensive subjects—comparison with bendrofluazide
Feasibility of enrolling patients to hypertension outcome trials based on an assessment of their cardiovascular risk
Carvedilol antagonizes pindolol-induced tachycardia
Early alterations in plasma markers of remodelling in heart failure patients treated with carvedilol
Superoxide-independent oxidant mechanisms for angiotensin II-induced contractions of human resistance arteries in health vs cardiac disease
Effect of Ba2+ and ouabain on bradykinin-mediated forearm vasodilatation
Haemodynamic and vascular effects of insulin in healthy subjects
Predicting the effect of dose staggering on metabolic drug-drug interactions
Inactivation of CYP2D6 by ecstasy
Effects of the selective COX-2 inhibitor, flosulide, on renal homeostasis in salt-loaded men
Poikilocapnic but not isocapnic hyperoxia causes an acute increase in arterial stiffness in healthy subjects
Flecanide toxicity
Does superoxide modify nitric oxide mediated responses in rat carotid arteries treated with lysophosphatylcholine or 7-ketocholesterol?
Prediction of age related changes in midazolam clearance in children
AHPPI survey of UK phase I units, 1999–2000
Variable ciclosporin exposure
A randomized, five-way, crossover study to compare the pharmacokinetics of two new and three marketed formulations of paracetamol in healthy volunteers
The immunogenicity of diclofenac and its acyl glucuronide metabolite in the mouse in vivo
Differential expression of matrix metalloproteinase-2 and -9 in the aorta and internal mammary artery of patients undergoing coronary artery bypass grafts
Determination of the role of CYPs 1A2, 2D6, and 2E1 in susceptibility to Parkinson's disease
Steady-state azathioprine metabolite concentrations in inflammatory bowel disease
Thioguanine-related veno-occlusive disease (VOD) of the liver in children with acute lymphoblastic leukaemia (ALL)
Assessing perceptions of benefit and harm of common drug therapies using therapeutic scenarios
Audit of a nurse-led warfarin anticoagulant clinic
A discordance of CYP2D6 genotype and phenotype in patients undergoing methadone maintenance treatment
Optimal number of subjects and sampling time to assess CYP2D6 activity using the plasma dextromethorphan/dextrorphan metabolic ratio
Urinary 6β-hydroxycortisol
NFκB in human neutrophils
Effects of atropine and low-dose pirenzepine on human β-adrenoceptor mediated increases in heart rate and contractility in vivo
Agonist-induced desensitization of β2-adrenoceptor-mediated venodilation and cardiac responses in subjects with the Thr164Ile β2-adrenoceptor
Effects of the Gln27Glu- and the Arg16Gly-β2-adrenoceptor polymorphisms on agonist-induced desensitization of β2-adrenoceptor-mediated venodilation in vivo
Effects of single doses of TAK-013, a new non-peptide orally active gonadotropin-releasing hormone antagonist, in healthy young men
Effects of a fixed dose of Melissa officinalis extract in Alzheimer's disease
Distribution of antigen formation
Influence of CYP2D6 and CYP2C19 genotypes on the QTc intervals of psychiatric patients taking thioridazine
In vitro prediction of population in vivo drug clearance using updated scaling factors
Transcription factor regulation and gene expression in response to the antipsychotic, clozapine
No adverse haemodynamic interaction between sildenafil (Viagra) and alcohol in healthy volunteers
Adults' reactions to inhaled denatonium benzoate (Bitrex®)
Superoxide anion contributes to angiotensin-II mediated contraction in human radial arteries in patients with coronary artery disease
Factors influencing switching from non-selective to selective non-steroidal anti-inflammatory drugs (NSAIDS)
The ethics of drug development and the Declaration of Helsinki
Nebivolol reduces large artery stiffness in vivo