Drug regulation & therapeutic efficacy
Phosphodiesterase 4 inhibitors in chronic obstructive pulmonary disease
Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin
Eprosartan modulates the reflex activation of the sympathetic nervous system in sodium restricted healthy humans
Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease
Safety, tolerability and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects
Mechanistic modelling of tesaglitazar pharmacokinetic data in subjects with various degrees of renal function – evidence of interconversion
Acute passive cigarette smoke exposure and inhaled human insulin (Exubera®) pharmacokinetics
Estimation of the impact of noncompliance on pharmacokinetics
Diclofenac readily penetrates the cerebrospinal fluid in children
Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia
Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9
UGT1A6 genotype-related pharmacokinetics of deferiprone (L1) in healthy volunteers
The association of adiponectin allele 45T/G and −11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients
Selective COX-2 inhibitors, NSAIDs and congestive heart failure
Clinically informative measures of the effect of drugs or other interventions
Trends in the methodological quality of published randomized controlled trials on antibacterial agents
Thrombolysis or nothing for acute myocardial infarction? It's all the same!
Graft rejection
Assessing general practitioners' prescribing behaviour in elderly patients with concealed renal failure
Lean body mass normalizes the effect of obesity on renal function
A well-tolerated 5-FU-based treatment subsequent to severe capecitabine-induced toxicity in a DPD-deficient patient
Suspected drug reaction with piperacillin/tazobactam, in a premature infant
Exploring the nature and type of interventions made by clinical pharmacists within an Integrated Medicines Management service
Validation of a medical student formulary by F1 prescribing questionnaire
Development of a core medical student formulary for prioritizing learning by prescribing audit
No more pharmacology? Pharmacists' and stakeholders' views on supplementary prescribing course content
Postconditioning protects against endothelial ischaemia-reperfusion injury in humans
Dose-response relationship between alcohol intake causes arterial and myocardial stiffening and left ventricular hypertrophy
M2 receptor activation modulates human and guinea pig detrusor contractions via cAMP inhibition
Endothelin-A receptor antagonism offers patients with chronic kidney disease cardiovascular and renal protection
Development of a routine test of platelet reactivity
Deprivation-based cardiovascular risk scores may lead to postcode prescribing
Heart rate corrected QT intervals in patients taking chronic tricyclic antidepressant therapy
The missing link between clinical endpoints and pharmacological receptor systems in depression
A clinical trial of modafinil treatment in children and adolescents with attention deficit hyperactivity disorder
A placebo controlled trial of the selegiline added to risperidone in chronic schizophrenia
Further evidence that benzodiazepines are not anxiolytic from multiple strains of mice with variable levels of innate anxiety in the 3D maze open space test
Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with p-phenylenediamine and Bandrowski's base
p-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye
Etoposide catechol, is it an important metabolite?
Use of the anti-tussive agent, glaucine, as a recreational drug of abuse
Emerging gender differences in the measurement of quality indicators in diabetic patients, after the introduction of a new national primary care contract
Intranasal insulin spray (NasulinTM) in healthy subjects
Intrasubject variability of electrocardiographic parameters in healthy volunteers and assessment of QT correction factors
Inhibition of platelet aggregation by aspirin in vitro varies considerably between healthy subjects
Clinical outcomes of metformin in patients with heart failure and type 2 diabetes
Nebivolol, but not atenolol, reduces wave reflection and improves pulse pressure amplification in hypertension
A novel renal injury biomarker predicts acute renal dysfunction after cardiac surgery
Serotonin transporter promoter polymorphism and antidepressant efficacy
Antihypertensive choice and neuropsychological function in chronic kidney disease patients
Primary Care prescribing practice in the treatment of hypertension in women of childbearing age referred to a Secondary Care specialist clinic
Effect of chronic rimonabant treatment on antidepressant-related protein expression
Assessment of drug treatment in patients attending a hospital Diabetes clinic
Urinary microparticles are a source of protein for biomarker discovery in sepsis
CYP2C9 gene variation and therapeutic response to sulphonylureas in type-2 diabetics
Comparison of thiopurine dose intensity, thiopurine metabolism and neutropenia in children with acute lymphoblastic leukaemia taking thioguanine or mercaptopurine
The clinical pharmacology of thioguanine vs. mercaptopurine in ALL97, a randomized trial for the treatment of childhood lymphoblastic leukaemia
Pharmacokinetics (PK) of lopinavir/ritonavir (LPV/r) 800/200 mg once daily and 400/100 mg twice daily over 72 h following drug intake cessation in healthy volunteers
Population pharmacokinetics of boosted saquinavir regimens in HIV-infected individuals
Oxidative stress is associated with augmented wave reflection, left ventrcular diastolic dysfunction and left ventricular hypertrophy
A mechanistic investigation into the binding of PPD to a cysteine containing peptide and the model protein glutathione-S-transferase Pi
Stimulation of nitroso sulfamethoxazole-specific T-cells with structurally-related hydroxylamine and nitroso metabolites
Fesoterodine pharmacokinetics in subjects with renal impairment vs. healthy subjects
Cardiovascular risk factors and their management in renal transplant recipients
The enterosalivary bioconversion of nitrate to nitrite underlies the blood pressure (BP) lowering and anti-platelet effects of a dietary nitrate load
Pharmacokinetic profile of fesoterodine, a novel antimuscarinic treatment for overactive bladder
Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base
Metabolic activation of nevirapine in human and rat systems
A randomized, single-dose, two-period, cross-over pharmacokinetic study to compare TDS®-diazepam with rectal diazepam in healthy adult subjects
The pharmacokinetic profile of warfarin
Effect of pentazocine-diazepam interaction on sleep and analgesic profile in mice
The effect of paracetamol (acetaminophen) on midazolam pharmacokinetics in humans
Obesity and not metabolic syndrome influences the response to antihypertensive therapy
Audit of 24 h ambulatory ECG recordings in a cohort of healthy volunteers
Equivalence of inhaled and nebulized salbutamol in the assessment of endothelial dysfunction