British Journal of Clinical Pharmacology
Editors’ Report, 2012
Cannabidiol as potential anticancer drug
Is the cardiovascular system a therapeutic target for cannabidiol?
Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
Pharmacogenomics of warfarin in populations of African descent
Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?
A systematic review of educational interventions to change behaviour of prescribers in hospital settings, with a particular emphasis on new prescribers
Online learning applied to a course on rational therapeutics: an international comparison between final year students of two medical schools
Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men
Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers
An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin
Relationship between the receptor occupancy profile and pleiotropic effects of angiotensin II receptor blockers
Low doses of fludrocortisone and hydrocortisone, alone or in combination, on vascular responsiveness to phenylephrine in healthy volunteers
The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers
The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors
Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
Assessment of potential drug interactions by characterization of human drug metabolism pathways using non-invasive bile sampling
Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity
Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin
Association between eIF3α polymorphism and severe toxicity caused by platinum-based chemotherapy in non-small cell lung cancer patients
First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials
Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers
Effectiveness of a single fixed dose of rasburicase 3 mg in the management of tumour lysis syndrome
Rifampicin and dabigatran etexilate: a place for laboratory coagulation monitoring
Response to the letter by Dr Chin and co-workers
Renal cell carcinoma. Translational biology, personalized medicine and novel therapeutic targets Editor(s) by Robert A. Figlin, W. Kimryn Rathmell & Brian I. Rini. Published by Springer, New York, USA, 2012. 327 pp, price $189.00, ISBN: 978-1-4614-2399-7
FASTtrack: Pharmacology, 2nd edn by Michael D. Randall, David A. Kendall, Stephen PH Alexander. Published by Pharmacology Press, London, 2012. 288 pp, paperback price £22.99, ISBN: 978 0 85711 057 2
Translation Section
A PHASE I STUDY, IN HEALTHY SUBJECTS TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF ANTI-VWF NANOBODY® ADMINISTERED SUBCUTANEOUSLY
PHARMACOLOGICAL SENSITIVITY OF HUMAN EXPERIMENTAL HYPERALGESIA PAIN MODELS: A LITERATURE REVIEW
POINT-OF-CARE DRUGS OF ABUSE TESTING IN THE EMERGENCY DEPARTMENT: EVALUATION AFTER TWO YEARS
MATURATION OF GFR IN PRETERM AND TERM NEONATES REFLECTED BY CLEARANCE OF DIFFERENT ANTIBIOTICS
PHASE I/II AND PHARMACOLOGICAL STUDY OF DOCETAXEL, OXALIPLATIN AND CAPECITABINE IN PATIENTS WITH ADVANCED CANCER OF THE STOMACH OR THE GASTRO-ESOPHAGEAL JUNCTION
PREVALENCE OF INSULIN RESISTANCE AND TYPE 2 DIABETES MELLITUS IN OVERWEIGHT AND OBESE CHILDREN AND ADOLESCENTS
OPTIMIZING MONITORING STRATEGIES OF TRASTUZUMAB INDUCED CARDIOTOXICITY USING AN IN SILICO SIMULATION FRAMEWORK
SCREEN: THE RELEVANCE OF DIFFERENT VARIABLES WHEN PERFORMING MEDICATION REVIEWS
POPULATION PHARMACOKINETICS OF MIDAZOLAM FROM PRETERM NEONATES TO ADULTS: A MATURATION MODEL
THE EFFECT OF INSTRUCTION MANUALS ON COMPLETENESS OF ELECTRONIC PATIENT RECORDS IN COMMUNITY PHARMACIES FOR PATIENTS DISCHARGED FROM HOSPITAL
SUCCESSFUL TREATMENT OF MOLYBDENUM COFACTOR TYPE A DEFICIENCY (MoCD-A), A RARE FATAL METABOLIC DISORDER IN EARLY INFANTS, WITH CYCLIC PYRANOPTERIN MONOPHOSPHATE
HOME BASED SAMPLING USING DRIED BLOOD SPOTS FOR THERAPEUTIC DRUG MONITORING OF ANTIRETROVIRAL DRUGS
INTRAVENOUS PARACETAMOL PHARMACOKINETICS IN YOUNG WOMEN: AT DELIVERY, DURING POSTPARTUM AND IN HEALTY VOLUNTEERS
EXPLORATORY STUDY ON THE CORRELATION BETWEEN SUNITINIB SWEAT SECRETION AND SKIN TOXICITIES
CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) POLYMORPHISMS AFFECT SEX-DEPENDENT RESPONSE TO STATIN THERAPY
A CASE OF HYPERTENSION ON DEXAMPHETAMINE, CONTROLLED BY ADDING CLONIDINE
CARE MUCH: CYTOSTATIC AGENTS, THEIR RISKS AND EFFECTS: MEDICATION SURVEILLANCE UNDER CONSTRUCTION IN HOSPITAL PHARMACIES: PRELIMINARY RESULTS
ALCOHOL EFFECTS ON CENTRAL AND AUTONOMOUS NERVOUS SYSTEM PARAMETERS IN ADOLESCENTS
USE OF BOOSTED PI WORSENS TDF-ASSOCIATED RENAL FUNCTION LOSS AND RALTEGRAVIR APPEARS TO OFFER SOME PROTECTION: RESULTS FROM A COHORT OF HIV-POSITIVE INDIVIDUALS
EXPLORING COVARIATES OF NEONATAL PROPOFOL CLEARANCE: DOES INDIRECT HYPERBILIRUBINAEMIA MATTERS?
IS TREX1 -MUTATION ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN RVCL-PATIENTS?
FACTORS ASSOCIATED WITH HIGH LEVELS OF EXHALED NITRIC OXIDE IN CHILDREN USING ASTHMA MEDICATION
THE ALLOMETRIC EXPONENT FOR MATURATION OF PROPOFOL CLEARANCE VARIES DEPENDING ON AGE RANGES IN THE SELECTED DATASETS
ADHERENCE TO GUIDELINES FOR THE PRESCRIBING OF COMBINATIONS OF ANTITHROMBOTIC AGENTS
THE EFFECT OF BENZODIAZEPINES ON POSTTRAUMATIC STRESS DISORDER
IDENTIFICATION OF DRUG-RELATED PROBLEMS BY A CLINICAL PHARMACIST IN ADDITION TO COMPUTERIZED PHYSICIAN ORDER ENTRY ALERTS