Issue highlights
Big Data: Challenges and opportunities for clinical pharmacology
Statin therapy and plasma free fatty acids: a systematic review and meta-analysis of controlled clinical trials
Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: a systematic review and meta-analysis
Reproductive outcomes following hydroxychloroquine use for autoimmune diseases: a systematic review and meta-analysis
Review of commonly used age-based weight estimates for paediatric drug dosing in relation to the pharmacokinetic properties of resuscitation drugs
The potential exploitation of research participants in high income countries who lack access to health care
Dissociation between systemic and pulmonary anti-inflammatory effects of dexamethasone in humans
The effect of LCZ696 (sacubitril/valsartan) on amyloid-β concentrations in cerebrospinal fluid in healthy subjects
External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients
Pharmacokinetics and safety of single doses of tabalumab in subjects with rheumatoid arthritis or systemic lupus erythematosus
Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients
Pharmacokinetics and tolerability of paritaprevir, a direct acting antiviral agent for hepatitis C virus treatment, with and without ritonavir in healthy volunteers
Influence of tumour burden on trastuzumab pharmacokinetics in HER2 positive non-metastatic breast cancer
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment
Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor
Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects
Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer
Opioids and COPD
Evaluating pharmacotherapy education: urgent need for hard outcomes
Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II
Retraction: ‘rhBNP therapy can improve clinical outcomes and reduce in-hospital mortality compared with dobutamine in heart failure patients: a meta-analysis’ by Ming-Yi Lv, Shu-Ling Deng and Xiao-Feng Long