Research Snippets
Therapeutic advances and shift in disease paradigm for atopic dermatitis
The impact of treatment with tumour necrosis factor-α antagonists on the course of chronic viral infections
Whither… the future for contact dermatitis? A report from the 2007 International Review of Current Problems in Contact Dermatitis
Extensive venous malformation, disseminated intravascular coagulopathy and anticoagulation
Familial capillary malformations caused by RASA1 mutation
Kasabach-Merritt syndrome caused by congenital haemangioma
Successful resection of a giant lymphatic malformation in an infant
Two-year outcome of bleomycin sclerotherapy treatment of vascular anomalies
Glomuvenous malformation
CINCA-like syndrome treated with etanercept
Hyperpigmented linear lesions as a manifestation of triple mosaicism
Usefulness of the QuantiFERON test in the confirmation of latent tuberculosis in association with erythema induratum
Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy
Aplasia cutis in conjunction with fetus papyraceus
Granulomatous skin lesions in association with immunodeficiency
Epidermolysis bullosa simplex with mottled pigmentation caused by a novel keratin 5 gene mutation
Pachyonychia congenita mimicking chronic mucocutaneous candidiasis
Fabricated or induced illness mimicking epidermolysis bullosa
Severe congenital cutis laxa with primary ciliary dyskinesia and situs inversus
A unique skin presentation associated with insulin-resistant diabetes
Is atopic dermatitis replacing psoriasis and seborrhoeic dermatitis in children?
Nonmast cell gastrointestinal disease in diffuse cutaneous mastocytosis
Prenatal onset of localized scleroderma causing facial hemiatrophy and hemiplegia
A unilateral facial mass in a neonate
Vulval melanoma in a child
Mucous membrane pemphigoid in a series of seven children and a review of all previously reported childhood cases
Erythromelalgia of the ears successfully treated with clonidine
Neonatal and infantile erythroderma
A case of infantile myofibromatosis
Cochrane systematic review
Additional filaggrin polymorphisms in early-onset and persistent atopic eczema
Regular antihelminthic therapy increases allergen skin sensitization
PHACES syndrome
Segmental haemangioma
A memorable patient
Neonatal vesiculopustular eruption associated with transient abnormal myelopoiesis and Down syndrome
Onychomycosis in an immunosuppressed child
Mobile phone dermatitis
The use of systemic steroids in haemangioma
Guidelines for topical photodynamic therapy
Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives
Gene expression study of IL10 family genes in vitiligo skin biopsies, peripheral blood mononuclear cells and sera
Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas
Susceptibility testing and resistance phenotype detection in Staphylococcus aureus strains isolated from patients with atopic dermatitis, with apparent and recurrent skin colonization
The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit
Occupational carprofen photoallergic contact dermatitis
Outcomes of treatment of nine cases of recalcitrant severe hidradenitis suppurativa with carbon dioxide laser
Superficial acral fibromyxoma
Economic evaluation of maintenance treatment with tacrolimus 0·1% ointment in adults with moderate to severe atopic dermatitis
Psoriasis and the risk of incident diabetes mellitus
Infantile-onset cutaneous T-cell lymphoma
Polymorphic light eruption and skin cancer prevalence
Proactive disease management with 0·03% tacrolimus ointment for children with atopic dermatitis
Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis
Clear differences in adiponectin level and glutathione redox status revealed in obese and normal-weight patients with psoriasis
Control of salicylate intolerance with fish oils
Weber–Cockayne type of epidermolysis bullosa simplex associated with a novel mutation in keratin 5 and amyloid deposits
A novel GJB6 missense mutation in hidrotic ectodermal dysplasia 2 (Clouston syndrome) broadens its genotypic basis
Superficial pyoderma gangrenosum responding to treatment with isotretinoin
Development of squamous cell carcinomas in Darier disease
Thresholds, dose–response relationships and dose metrics in allergic contact dermatitis
Thresholds, dose–response relationships and dose metrics in allergic contact dermatitis
Cutaneous infection due to Mycobacterium interjectum in an immunosuppressed patient with microscopic polyangiitis
News and Notices
Characterization of ZNF313/RNF114 as a novel psoriasis susceptibility gene
Replication of association of ZNF313/RNF114 locus on chromosome 20ql3 with psoriasis
Genome-wide scan reveals association of psoriasis with interleukin-23, Th2 and NF-kB pathways
Psoriasis is associated with copy number variation of genes involved in innate immunity and skin barrier function
Preliminary pharmacogenetic assessment of tumour necrosis factor (TNF) polymorphisms in psoriasis
PRINS, the psoriasis susceptibility related noncoding gene RNA interacts with chaperone molecules and regulates the gene expression of G1P3/F/6, an antiapoptotic, interferon-inducible protein
HLA-Cw6 allele confers sensitivity to efalizumab treatment in psoriasis
Comorbidities, healthcare utilization and genetics of psoriasis in a founder population
A new tool assessing quality of life in patients with psoriasis
Evaluation of a novel three-dimensional Psoriasis Severity Index (PSI) by comparison with the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI)
Clinical predictors for psoriatic arthritis in patients with psoriasis
The cytokine pattern of lesional psoriatic T-cell clones
Phenotype and functional confirmation that Thl7 cells constitute the major CD4 population in psoriatic lesions and are likely to have a major pathogenic role
The role of γç T cells in psoriasis
Induction of interleukin-17+ T-cell trafficking and development by interferon-γ
Development and validation of human psoriatic skin equivalents
Induced expression of vanins in lesional psoriatic skin
Alleviation of psoriasis upon genetic knockdown of human tumour necrosis factor-α by lentivirus-encoded short hairpin RNA in a xenograft transplantation model
Preferential inhibition of interleukin (IL)-17C, IL-1β and p38 mitogen-activated protein kinase in psoriatic skin by antitumour necrosis factor-α therapy
Activation of PPAR d causes a psoriasis-like skin disease in vivo
Thl7/Treg paradigm
Adalimumab therapy rapidly inhibits p38 mitogen-activated protein kinase activity in lesional psoriatic skin preceding clinical improvement
Identification of genetic risk markers of efalizumab response
P01
Treatment response in clinical practice is in agreement with those obtained in randomized clinical trials (RCT)
P03
Simple and rapid screening for HLA-Cw*06 in patients with psoriasis from Poland
Adalimumab in combination with methotrexate more effectively reduces the numbers of different inflammatory cell types in lesional psoriatic skin than does single treatment with adalimumab or methotrexate
Differences in antihypertensive and antidiabetic therapy in severely affected hospitalized patients with psoriasis compared with the general population in Germany
Prevalence of ‘lifestyle factors’ in severely affected and hospitalized German psoriasis patients
Expectations and satisfaction of psoriasis patients at first presentation to a university hospital psoriasis-centre outpatients service
Detection of latent tuberculosis in patients with psoriasis before antitumour necrosis factor therapy
Weight loss improves the response of obese patients with moderate to severe chronic plaque psoriasis to low-dose ciclosporin therapy
Pharmacokinetics of dimethylfumarate in a CaCo-2-transwell system
Genetically programmed differences in epidermal host defence between patients with psoriasis or atopic dermatitis
Treatment of acrodermatitis continua of Hallopeau with adalimumab
Eleven years of safety experience with efalizumab
New insights into the mode of action of the antipsoriatic drug dimethylfumarate
Infliximab therapy correlates with an increase in polyclonal CD4+CD25high regulatory T cells in psoriasis patients
In lesional psoriatic skin the expression and phosphorylation of eukaryotic initiation factor 4E and the expression of 4E-BP1 are increased
Correlations between proinflammatory and anti-inflammatory cytokines and the T-score of bone mineral density in psoriatic arthritis
Indigo naturalis upregulates epidermal tight junction proteins in psoriasis and cultured keratinocytes
P20
Dimethylfumarate inhibits macrophage inhibitory factor (MIF)-induced proliferation of keratinocytes
Defective p75 neurotrophin receptor in transit amplifying cells renders psoriatic keratinocytes more resistant to apoptosis
Caspase-1, caspase-5 and ASC are upregulated in lesional psoriatic skin
MicroRNA-mediated regulation of skin inflammation in psoriasis
Investigating the expression of the susceptibility allele HLA-Cw6 in psoriasis using a specific single-chain fragment antibody
Thl7 cells are present in both normal and psoriatic skin, but are only activated in lesional psoriatic skin
Marked improvement of nail psoriasis during treatment with adalimumab
A pharmacogenetic study on the efficacy of methotrexate in psoriatic arthritis
Results of a randomized, double-blind study to evaluate the efficacy and safety of etanercept in patients with psoriasis and psoriatic arthritis
Improvement in the Dermatology Life Quality Index for patients with psoriatic arthritis when treated with etanercept
The use of biologic therapies for the treatment of moderate-to-severe psoriasis in UK clinical practice
Family aggregation in psoriasis and psoriatic arthritis
The prevalence of tissue transglutaminase antibody positivity in an Irish psoriatic population
P34
Epidermal growth factor receptor and interleukin-1 synergistically promote keratinocyte antimicrobial defences in a differentiation-dependent fashion
Haplotypes associated with alleles of the immunoglobulin heavy chain enhancer HS1,2 of the 3′ regulatory region in patients with psoriatic arthritis
Adalimumab for moderate to severe psoriasis
Cross-sectional survey of psoriasis occurrence and treatment in Slovakia
Diminished cognitive responses to facial expressions of disgust
Analysis of IL12B and IL23R alleles in clinical variants of psoriasis
The evaluation of morning cortisolaemia in patients treated with short-contact 0·05% clobetasol propionate shampoo once daily during 4 weeks therapy for scalp psoriasis
Alterations in major histocompatibility complex class I and II expression are not associated with impairment of Langerhans cell migration in the uninvolved skin of individuals with early-onset psoriasis
Inhibition of keratinocyte proliferation with a novel compound for the topical treatment of psoriasis and dermatitis
Results of effectiveness of a 12-week educational programme for patients with selected dermatoses
Evolution of psoriasis
P46
Remission and time of resolution of nail psoriasis
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin
Amphiregulin overexpression in a mouse model of ‘outside-in’ and its relevance to psoriasis pathogenesis
Psychosocial distress in psoriatic outpatients
Psoriasis
Efalizumab in the treatment of psoriasis and HCV+ hepatitis
Psoriasis and concomitant hypercholesterolaemia
Patient care for psoriasis in Germany
Effect of antitumour necrosis factor-α therapies on body composition in patients with psoriasis
Transcriptome modelling of psoriatic lesions to identify and subsequently characterize novel targets in cutaneous inflammation
Decrease of CDlla detection in costimulatory contact to dendritic cells in psoriatic plaque under efalizumab (Raptiva®) treatment as analysed by multiepitope ligand cartography
Ustekinumab neutralizes human interleukin (IL)-12− and IL-23-mediated Th1 and Th17 cell function and provides clinical benefit to patients with plaque psoriasis
The pharmacokinetics and pharmacodynamics of voclosporin in plaque psoriasis
Efficacy and safety of ustekinumab in moderate to severe psoriasis patients who were not candidates for treatment with conventional systemic therapy
Quantifying cardiovascular risk among patients with moderate to severe psoriasis
Impact of depression and anxiety on employability and productivity in patients with moderate to severe psoriasis
Ustekinumab decreases pathological immune infiltrates while normal leucocyte subsets are retained in skin and peripheral circulation
Open-label, prospective evaluation of adalimumab for psoriasis patients who were nonresponders to etanercept
Three-year registry data on biological treatment for psoriasis
Inpatient care for psoriasis
Lattice System Physician's Global Assessment validation for assessing psoriasis
Cost-effectiveness of biologics for moderate-to-severe psoriasis from the perspective of the Swiss healthcare system
Not all that looks like psoriasis is psoriasis