Editor’s Choice April 2012
A randomized trial of methotrexate vs. azathioprine for severe atopic eczema: a critical appraisal
Response to a randomized trial of methotrexate vs. azathioprine for severe atopic eczema: a critical appraisal
Commentary: are methotrexate and azathioprine really equivalent for treating severe atopic eczema?
Melanoma of the hand and foot: a distinct clinical variant of cutaneous melanoma
Frontalis-based island pedicle flaps for the single-stage repair of large defects on the forehead and frontal scalp
Patterns of sun protection for young children: do we deliver the right sun-protection messages?
New topical drug development in atopic dermatitis: a place for hope
Angiokeratoma: decision-making aid for the diagnosis of Fabry disease
Primary cutaneous Ewing sarcoma: a systematic review focused on treatment and outcome
Melanoma of the hand and foot: epidemiological, prognostic and genetic features. A systematic review
Confocal laser scanning microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails
Prevalence of food avoidance and food allergy in Chinese patients with chronic urticaria
Demodex-associated bacterial proteins induce neutrophil activation
Concentration variability of potent allergens of p - tert -butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR
Frontalis-based island pedicle flaps for the single-stage repair of large defects of the forehead and frontal scalp
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern
FGFR3 , PIK3CA and RAS mutations in benign lichenoid keratosis
Peripheral natural killer cells exhibit qualitative and quantitative changes in patients with psoriasis and atopic dermatitis
Analysis of three outcome measures in moderate to severe psoriasis: a registry-based study of 2450 patients
A comparison of patterns of sun protection during beach holidays and everyday outdoor activities in a population sample of young German children
Psoriasis and risk of nonfatal cardiovascular disease in U.S. women: a cohort study
A founder ectodysplasin A receptor ( EDAR ) mutation results in a high frequency of the autosomal recessive form of hypohidrotic ectodermal dysplasia in India
Clinical, molecular and biochemical characterization of nine Spanish families with Conradi–Hünermann–Happle syndrome: new insights into X-linked dominant chondrodysplasia punctata with a comprehensive review of the literature
Markers of oxidative stress are increased in exhaled breath condensates of children with atopic dermatitis
Combined treatment with immunoadsorption and rituximab leads to fast and prolonged clinical remission in difficult-to-treat pemphigus vulgaris
Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week, multicentre, randomized, placebo-controlled double-blind trial
Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial through up to 3 years
Erythrocyte sedimentation rate as an independent prognostic factor in mycosis fungoides
Pachyonychia congenita patients with mutations in KRT6A have more extensive disease compared with patients who have mutations in KRT16
Bacteriology of hidradenitis suppurativa exacerbations and deep tissue cultures obtained during carbon dioxide laser treatment
Comparison of Skindex-29, Dermatology Life Quality Index, Psoriasis Disability Index and Medical Outcome Study Short Form 36 in patients with mild to severe psoriasis
Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation
Sporotrichoid-like calcinosis cutis and calcifications in vessel walls and eccrine sweat glands following intravenous infusion of calcium gluconate
Compound heterozygous mutations in desmoplakin cause skin fragility and woolly hair
Genotype analysis in a patient with oculocutaneous albinism 1 minimal pigment type
Increased risk of psoriasis among patients with schizophrenia: a nationwide population-based study
Buschke–Ollendorff syndrome associated with hypertrophic scar formation: a possible role for LEMD3 mutation
Possible modifier effects of keratin 17 gene mutation on keratitis–ichthyosis–deafness syndrome
Clinically manifest X-linked recessive ichthyosis in a female due to a homozygous interstitial 1·6-Mb deletion of Xp22.31
Acute phototoxicity induced by methylene blue-assisted parathyroidectomy: an unreported risk of a common procedure
News and Notices
p63, an alternative p53 repressor in melanoma which confers chemoresistance and a poor prognosis
WIPI-1: a novel autophagy inhibitory protein in melanoma
p62 as a biomarker of malignant melanoma
Psoriasis and biomarkers of cardiovascular disease
Biomarker discovery using integrative systems analysis of whole tissue models
B-cell growth factors in autoimmune blistering skin disease
Identification of the human cross-presenting migratory dendritic cell
A novel epidermal explant model to study Langerhans cell mobilization in aged skin
Kinetics and antigen specificity of CD4+ memory and regulatory T cells during cutaneous immune responses to varicella-zoster virus in young and old individuals
Systemic therapies restore epidermal Langerhans cell migration in early-onset psoriasis
Superior activation of CD8+ lymphocytes by primary human Langerhans cells is CD70 dependent
The peritumoral infiltrate of human cutaneous squamous cell carcinomas contains regulatory T cells which suppress peritumoral effector T-lymphocyte function
A novel skin-resident vitamin D3-inducible human dendritic cell playing a critical role in tissue homeostasis and immunoregulation, as demonstrated in humanized mouse models of disease
IgE antibodies targeting a major melanoma antigen are more effective than IgG antibodies for tumour protection in a humanized melanoma model
The psoriasis-protective IL23R A/Glu381 allele promotes interleukin-23 unresponsiveness in human memory T helper (Th) 17 cells and impairs Th17 response in patients with psoriasis
The effects of Sophora angustifolia and other natural plant extracts on melanogenesis and melanin transfer in human skin cells
Association between melanocortin-1-receptor (MC1R) genotype and phenotype of congenital melanocytic naevi reveals a wider role for MC1R in utero
Acute ultraviolet B-induced changes in epidermal tight junction protein expression are dependent on the differentiation state of keratinocytes
Predicting the differential susceptibility of dermal extracellular matrix proteins to photodegradation by solar-simulated radiation
Investigating the protective effects of the mitochondrial located antioxidants MitoQ and Tiron in ultraviolet-exposed human skin cells
Methylation profiling of cutaneous squamous cell carcinoma reveals an embryonic stem cell signature among differentially methylated genes
Phospholipase C signalling in cutaneous squamous cell carcinoma
Epidermal growth factor receptor signalling in basal cell carcinoma
RHBDF2 mutations affect epidermal growth factor signalling in tylosis with oesophageal cancer
RNAi depletion of PRSS21 induces apoptosis in cutaneous squamous cell carcinoma keratinocytes
The organic anion transporter SLCO1B3 is regulated by type VII collagen expression in aggressive cutaneous squamous cell carcinoma
Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo
The role of Toll-like receptor-2 and nuclear factor-κB signalling in hyperkeratosis in lamellar ichthyosis
Clinical grade lentiviral vector production for inherited skin disease
Transcriptome analysis of skin reveals differences between atopic eczema cases stratified for filaggrin genotype
Cx43, insulin-like growth factor (IGF)-I and IGF-binding protein-5 modulate cell migration in scrape-wounded human keratinocyte and organotypic skin models
Epithelial to mesenchymal transition in the cutaneous epithelium is reversible: implications for the pathogenesis and treatment of scleroderma
A genetic and functional link between ADAM17 and RHBDF2 in tylosis with oesophageal cancer
Akt1 controls key processes in epidermal terminal differentiation and cornified envelope formation
A quantitative molecular diagnostic system for predicting progression of vulval intraepithelial neoplasia to invasive squamous cell carcinoma
In vitro modelling of basal cell carcinoma reveals a novel PTCH1-GLI1 signalling axis that is unresponsive to Smoothened inhibitors in human keratinocytes
The cutaneous Langerhans cell histiocytosis microenvironment
Matrix elasticity regulates human keratinocyte proliferation
Intrinsic skin ageing is associated with increased amine oxidase activity in situ
Mitochondrial and extracellular matrix dysfunction characterized an in vitro model of ageing primary human dermal fibroblasts
Autophagy in epidermis
Induction of chloracneform changes by TCDD (dioxin) in an epidermal equivalent model
The role of the basement membrane in normal epidermal homeostasis
Mutations in the γ-secretase genes NCSTN, PSENEN and PSEN1 underlie rare forms of hidradenitis suppurativa (acne inversa)
Disease subphenotypes based on cytokine-specific molecular signatures: moving towards stratified medicine
Analysis of the consequences of SOSTDC1 loss in linear morphoea
Sequencing of the γ-secretase complex in Singaporean patients with acne inversa reveals a novel mutation in nicastrin, but suggests other mechanisms must be present
Epidermal growth factor signalling in the pathogenesis of Langerhans cell histiocytosis
Variations in SEPT6 expression reflect progression of melanoma
Next-generation sequencing in genetic diagnosis of skin disease
Aged and photoaged skin is associated with a low-grade inflammatory cell infiltrate
Identification of tyrosine hydroxylase autoantibody epitopes in patients with vitiligo and alopecia areata
Interleukin-10-producing B-cell populations in melanoma
Increased CD4 and CD8 T-cell differentiation in elderly patients with melanoma
MicroRNA-146a modulates proinflammatory cytokines in the skin
Wnt5a inhibits the CpG oligodeoxynucleotide-triggered activation of human plasmacytoid dendritic cells
Early events in the recall response to varicella-zoster virus skin antigen in ageing
Biomarker discovery in psoriasis using a multiparameter flow cytometry platform
The characterization of tight junction function in the human hair follicle
Probiotic lactobacilli protect human primary keratino cytes from the effects of Staphylococcus aureus
HMGB1 serum levels as a potential new biomarker of disease severity in recessive dystrophic epidermolysis bullosa
Narrowband ultraviolet B therapy increases the circulating frequency of regulatory T cells in psoriasis
Mitochondrial DNA, a reliable biomarker for measuring the effect of cumulative ultraviolet irradiation exposure in whales (cetaceans)
Incidence, mortality and disease associations of pyoderma gangrenosum in the U.K.: a retrospective cohort study
Reduction in the appearance of facial solar lentigines following use of either hydroquinone 4% or a cosmetic ‘antiageing’ regimen