Thromboembolism in childhood : a prospective two-year BPSU study in the United Kingdom. February 2001–February 2003
Outcome of Philadelphia positive (Ph+) childhood acute lymphoblastic leukaemia (ALL) on the MRC ALL 97/01 trial
Constitutional variants in the Fanconi anaemia group G gene (FANCG) in sporadic childhood acute myeloid leukaemia
Prodaptin-linked CD59, a membrane-targeted recombinant CD59, coats PNH red cells in vitro and protects murine red cells from human complement mediated lysis when given in vivo
Eculizumab, a C5 complement-blocking antibody, controls haemolysis in paroxysmal nocturnal haemoglobinuria (PNH) with responses maintained over a prolonged period of therapy
A genetic interaction between chromosome 8q and the β-globin complex influences the switch from foetal to adult haemoglobin
Erythropoietin used early after allogeneic transplantation is effective at reducing anaemia and the need for blood transfusions
Outcome of allogeneic stem cell transplantation in adults with high-risk myeloid malignancies using an alemtuzemab based reduced-intensity-conditioning regimen
Exploiting alloreactivity in relapsed and refractory Hodgkin Lymphoma : long-term follow-up of a T-cell-depleted reduced intensity transplant protocol
The effect of conditioning therapy on Langerhans' cell density and phenotype in human bone marrow transplantation
Co-transplantation of murine mesenchymal stem cells and murine haemopoietic stem cells improves haemopoietic engraftment in an irradiated murine recipient
Reconstitution of cytomegalovirus (CMV)-specific CD4+ T cells following allogeneic stem cells transplantation – impact of conditioning regimen, GvHD and source of stem cells
Use of serum-free light chain assays for determining complete remission in patients with multiple myeloma
The ATR-p53 pathway is suppressed in non-cycling normal and malignant lymphocytes
Evidence for a primitive cell origin of acute lymphoblastic leukaemia
Characterization of T-ALL progenitor cells
Red cell autoantigen presentation by chronic lymphocytic leukaemia cells : a new mechanism underlying autoimmune disease
Protein expression profiling confirms the close association between CLUS and CLL
The proliferating cells in CLL have a unique immunophenotype
Analysis of IgH rearrangements in class-switched IgG+ B-CLL
Relationship between p53 dysfunction and karyotypic abnormalities in chronic lymphocytic leukaemia
Cytomegalovirus (CMV) infection in patients treated with alemtuzumab and other non-transplant therapies – a manageable complication with early detection by preemptive screening
Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols
Detection of p53 dysfunction in chronic lymphocytic leukaemia cells : a comparison of Western blotting and flow cytometry
The acquired CD40 ligand deficiency observed in patients with B-CLL is reversible and due to soluble leukaemia derived factor(s)
Do we need to monitor MGUS patients indefinitely?
The natural history of ‘early’ CLL
Soluble syndecan-1 modulates myeloma growth but not through FGF signalling
Bcl-2 phosphorylation and up-regulation of Mcl-1 contribute to the drug resistant phenotype of B-CLL cells that survive in vitro exposure to chemotherapeutic drugs
CD38+ and CD38- B-CLL subsets from patients with bimodal expression of the CD38 antigen exhibit distinct cell cycle distribution and Bcl-2 family protein expression
Primary central nervous system lymphoma (PCNSL) : a single centre experience of 55 unselected cases
Clinical, immunophenotypic and cytogenetic features of ‘unclassified’, t(11;14) negative, CD5+ B-cell leukaemia
A randomized study (WOSMM1) comparing the oral regimen Z-Dex with VAD as induction therapy for newly diagnosed patients with multiple myeloma
Zap-70 expression in CLL. Correlation with clinical and biological features
Diagnosis of CD5+ lymphocytosis : correlation between t(11;14) by FISH and cyclin D1 staining on tissue sections
The combined PET/CT scanner – an invaluable aid in the management of complex lymphoma patients from Northern Ireland
The role of flow cytometry on lymph node tissue as a rapid decision making tool for lymphoproliferative disease
Bone lesions at diagnosis in myeloma patients : age, subtype and β*2 microglobulin
Gene expression profiling identifies a sub-population of AML patients most likely to respond to the FLT3 inhibitor CEP701
Gene array profiling of the effect of FLT3 mutations in AML
Prognostic factors for response parameters and overall survival in patients with multiple myeloma following treatment with bortezomib
Interleukin-1b maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways
Overexpression of total cellular phosphoserine in AML blasts with functional p-glycoprotein
The CD4 T-helper response to b3a2 BCR-ABL is deficient in chronic myeloid leukaemia (CML) and normal subjects
L3MBTL, a candidate 20q tumour suppressor gene is not mutated in patients with myeloid malignancies and displays monoallelic methylation
Clonality of dendritic cells from chronic myeloid leukaemia patients treated with imatinib
Bcr-Abl down-regulates CCN3 expression
GADD45 expression correlates with drug resistance phenotype and functional Pgp status in AML
Comparison of signature gene profiles between cytogenetic risk group, FAB classification and WHO classification for AML
Identification of presentation acute myeloid leukaemia antigens in a testes cDNA library
Use of cDNA microarray analysis to identify cancer testes antigen expression in presentation acute myeloid leukaemia
Internal tandem duplications of FLT3 and partial tandem duplications of MLL can provide further stratification of the intermediate risk category of acute myeloid leukaemia
Neutrophil PRV-1 gene expression in myeloproliferative, myelodysplastic and reactive blood disorders
An audit of the use of imatinib in the treatment of chronic myeloid leukaemia in Scotland
Prognostic value of real-time quantification of XIAP and XAF-1 in AML
Mechanism of eosinophilia in 26 cases of persistent unexplained eosinophilia. Low incidence of FIP1L1-PDGFRA, TEL-PDGFRB and rare variant BCR ABL
Hsp90 as a target molecule for selective therapy in FLT3 positive AML
An investigation of the pro-apoptotic effect of the MEK/ERK inhibitor U0126 alone and in association with Ara-C in acute myeloid leukaemia
Dendritic cell-leukaemic blast fusion hybrids stimulate anti-leukaemic cytotoxicity in AML
Toxic megacolon due to invasive aspergillosis localized to the colon
Should patients who have spontaneous remission of acute leukaemia be treated with chemotherapy?
Clarithromycin, dexamethasone and low dose thalidomide (CDT) is effective therapy in relapsed/refractory myeloma and useful in patients with cytopenias
Clinical and experimental study on cardiac effects of general dosage arsenic trioxide on APL patients
The use of imatinib in the treatment of CML in patients over 65 years in Northern Ireland
Effect of Gemtuzumab Ozogamicin on the proliferation of acute myeloid leukaemia blast cells in vitro
Sensitivity and As2O3 concentration in cell
Random and contrast study on two arsenic trioxide administration methods in APL therapy
Arsenic trioxide inhibits proliferation and downregulates myc-associated zinc finger protein (MAZ) in primary acute myeloid leukaemia (AML) cells
Audit of febrile neutropenia in patients with acute leukaemia in a district general hospital
Intermediate purity factor VIII concentrate BPL 8Y as prophylaxis and treatment in congenital thrombotic thrombocytopenic purpura
Improved engraftment and survival rates in unrelated donor stem cell transplantation in MPS 1H (Hurler's syndrome) : a review of three UK centres
A possible role for recombination activating gene-1 (RAG-1) allotypes in the aetiology of childhood T-cell acute lymphoblastic leukaemia
Assessment of liver disease in transfusion dependent thalassaemia major
Enzyme replacement therapy prehaematopoietic stem cell transplantation (HSCT) in Hurler's disease
Outcome of sagittal sinus thrombosis associated with asparaginase therapy in childhood acute lymphoblastic leukaemia (ALL)
Toxicity associated with ELSPAR asparaginase in the induction–remission phase of treatment for childhood ALL
Role of serum methylmalonic acid, homocysteine and transcobalamin II in the diagnosis of vitamin B12 deficiency
Role of hydroxyurea (HU) in children with sickle cell disease (SCD)
The C598T VHL mutation arose in an ancestor common to Asian and Caucasian populations
Free circulating DNA as a biomarker for severity and prognosis in sickle cell disease
Surgery, preoperative transfusion and postoperative complications in patients with sickle cell disease : a survey in England
The Pro582Ser polymorphism in the VHL binding site of HIF-1α is present in patients with idiopathic erythrocytosis but does not diminish binding to pVHL
A novel mutation in the ALAS2 gene in a family with X-linked sideroblastic anaemia
HFE (haemochromatosis) mutations and myocardial infarction
Cannabis use in sickle cell disease : results of an anonymous patient survey
Tosoh-G7 HPLC system HbA2, HbF and HbS levels correlate significantly with in-house Kontron HPLC
Severe sideroblastic anaemia with raised erythrocyte protoporphyrins – a variant of erythropoietic protoporphyria (EPP)
Windy weather and acute pain in sickle cell disease
Vascular endothelial growth factor and proliferative retinopathy in sickle cell disease
Umbilical cord blood transplantation for paediatric haematological malignancies : single UK institution experience
Long-term follow-up of an alemtuzumab (CAMPATH-1H)- containing reduced intensity allogeneic transplant (RIT) regimen for relapsed and refractory non-Hodgkin's lymphoma (NHL)
Late reactivation of Epstein–Barr Virus (EBV) in recipients of non-myeloablative allogeneic stem cell transplantation conditioned with alemtuzumab
Very low dose aciclovir prophylaxis postallogeneic stem cell transplantation prevents varicella zoster infection without development of clinically relevant resistance
Changes in serum-free light chain concentrations as a marker of disease response in myeloma patients after autologous stem cell transplantation
High response rate to DLI based strategies for the treatment of refractory disease/relapse following allogeneic HSCT for lymphoproliferative disease
CD34 and/or CD3 add-back infusions improve donor chimaerism but do not impact lymphocyte subset recovery in children undergoing haplo-identical transplantation
A single centre experience of reduced intensity conditioned HSCT using BEAM-campath for low-grade lymphoid malignancies
Incidence and outcome of herpes simplex virus (HSV) and varicella zoster infection (VZV) following stem cell transplantation in the era of T-cell depletion and the use of non-myeloablative conditioning – implications for prophylactic strategies
Estimations of haematopoetic progenitor cells in peripheral blood by the Advia 120 and B-D Vantage flow cytometer : a direct comparison for the prediction of adequate collections
Long-term treatment of chronic graft versus host disease with extracorporeal photopheresis does not reduce the number of mononuclear cells that secrete TNF-α and interferon-γ
In vitro generation of T cells cytotoxic to allogeneic AML blasts
Nucleated cell doses collected from unrelated donor bone marrow harvests
Liver colonization from acetyl LDL incorporating endothelial cells in the mouse embryo
Automated analysis of reticulated platelets and its potential clinical value
Clinical and laboratory features of seven British kindreds with hereditary hyperferritinaemia cataract syndrome
A large multi-centre evaluation of the methodologies for the accurate platelet counting of severe thrombocytopenia
Transfusion related acute lung injury : a major cause of transfusion associated mortality and morbidity
Amotosalen hydrochloride (S-59) and UVA light treatment of cryosupernatant has no clinically significant effect on haemostatic proteins and appears suitable for plasma exchange in thrombotic thrombocytopenic purpura
Fibrin D-dimer is an independent predictor of future stroke in patients with atrial fibrillation
Gene defects in patients with factor XI deficiency
Heparin cofactor II, new insights into heparin binding
Thrombophilia in pregnancy : a systematic review
Homology modelling of mutations causing factor XI deficiency using related crystal structures and bioinformatics
A comparison of bleeding and rethrombosis rate in primary antiphospholipid syndrome and inherited thrombophilia at a target INR of 2.0–3.0
Ras promotes monocyte lineage selection
Profiling proteasome activity in multiple myeloma and lymphoma
Inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β) are anti-proliferative, induce apoptosis and down-regulate PA-requiring signalling pathways in ATRA sensitive and resistant myeloid cell lines
Defining complete Hox signatures in murine haematopoietic cells by Q-PCR
Regulation of Hox genes by IL-3 in 32D and FDCP-mix cells
Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQ01 pathway; possible mechanisms leading to the development of t-AML/MDS
Raf, PI3K and RalGDS each contribute to erythroid lineage misprogramming mediated by mutant Ras in primary human erythroid cells
Influx and efflux of imatinib are mediated by active transport via drug transporter proteins
Increased expression of the low affinity IgG receptor FcRγIIA (CD32) in platelet RNA from patients with chronic myeloproliferative disorders demonstrated by representational difference analysis
Improved quantitation of haematopoietic chimaerism by real-time polymerase chain reaction
Analysis of anagrelide-induced apoptosis in megakaryocytic cell lines
Isolation and properties of non-transduced and HoxB4- transduced bone-derived murine mesenchymal stem cells
Proteolytic activities of the proteasome in chronic myeloid leukaemia
Are we getting as much information as possible from bone marrow biopsies?
Detection in serum of tumour-derived antigen receptor DNA in chronic lymphoproliferative disorder patients
Effect of calcium on bone marrow-derived stromal cell growth and differentiation
Acetyl carnitine stimulates in vitro myeloid progenitor growth
Improving the accuracy of detection of t(11;14)(q13;q32) and t(14;18)(q32;q21) chromosomal translocations by PCR
Acute endothelial cell activation in the pathogenesis of severe and cerebral malaria
Prospective evaluation of a new algorithm for diagnosis of pulmonary embolism
Potentiation of fibrinolysis by inhibition of thrombin activatable fibrinolysis inhibitor in whole human blood
Low incidence of high titre FVIII inhibitors in previously untreated children with severe haemophilia A treated only with intermediate FVIII concentrate (BPL 8Y). Experience from five comprehensive care centres in the UK
Circulating endothelial cells predict outcomes in patients with acute coronary syndrome : relationship to plasma indices of endothelial damage/dysfunction and interleukin-6
Effects of hypobaric hypoxia on platelet activation and reactivity
Thrombin generation and correlation with bleeding tendency in inherited FXI deficiency
Successful use of magnetic resonance direct thrombus imaging (MRDTI) and inferior vena cava (IVC) filter insertion in pregnancy and the puerperium
Circulating platelet microparticles in patients with antiphospholipid antibodies
Defective fibrinolysis in children with severe haemophilia A
A second cohort of patients with coronary heart disease and reduced VWF cleaving protease activity
The combined use of D-dimers and diagnostic imaging in the exclusion of deep vein thrombosis in a nurse led outpatient service
Elevated factor VIII : C levels in patients with pulmonary hypertension. A marker of endothelial dysfunction?
Neutral endopeptidase inhibition potentiates bradykinin mediated vasodilatation and tissue plasminogen activator release in patients with heart failure on chronic angiotensin converting enzyme inhibitor therapy
Rebound elevation of factor VIII : C levels following successful treatment for acquired haemophilia
Audit of the management of thrombotic thrombocytopenic purpura in adult patients in Scotland
Thrombophilia in the black population : results of the Camberwell Thrombophilia Study
A UK survey of prophylaxis in paediatric patients with haemophilia
u-PA expression in normal myeloid differentiation and leukaemia
Protein Z concentrations in normal pregnancy
An analysis of the β2-glycoprotein I Cys306Gly polymorphism in patients with thrombotic and obstetric disorders
An analysis of the antiphospholipid antibody status of 111 women with late pregnancy morbidity
High pulse pressure but not mean arterial blood pressure is associated with abnormal thrombogenesis and endothelial damage/dysfunction in patients with coronary heart disease with and without hypertension
Impaired left ventricular diastolic function is associated with abnormal haemorheology, thrombogenesis and endothelial damage/dysfunction in patients with coronary heart disease
Platelet activation, coagulation and angiogenesis in breast and prostate cancer
Vaccino-associated immune thrombocytopenic purpura in childhood
Multi-centre survey of the management of antenatal venous thromboembolism in the UK and Ireland 2003–2004
A novel R1205C candidate type 1 von Willebrand disease mutation in the same codon as type 2 ‘Vincenza’ in two affected siblings of a Scottish family
Changes in plasma haemostatic markers with hospital-based versus home-based cardiac rehabilitation in patients with coronary heart disease : the Birmingham Rehabilitation Uptake Maximization Study (BRUM)
Incremental shuttle walking is associated with activation of haemostatic and haemorheologic markers in patients with coronary heart disease
Anti-hypertension treatment reduces platelet derived VEGF and angiopoietin-1 in hypertension
Soluble CD40 ligand, P-selectin, interleukin-6 and tissue factor in diabetes with and without overt cardiovascular disease
The effect of intensive multi-factorial intervention on soluble CD40 ligand, interleukin-6 and tissue factor in diabetes with and without overt cardiovascular disease
Plasma vascular endothelial growth factor, angiopoietin- 1, -2 and soluble Tie-2 levels in diabetes : relationship with glycaemia, microalbuminuria, endothelial damage/dysfunction and the effect of multi-factorial intervention
Comparison of multiplex PCR with thirdwave invader DNA analysis for the detection of the factor V Leiden and prothrombin 3′UTR gene mutations
Risk factor profile and provisional outcomes findings for confirmed venous thromboembolism : the VEenous thromboembolism RegIsTrY (VERITY)
A novel variant of acquired von Willebrand syndrome associated with systemic lupus erythematosus successfully managed with recombinant activated factor VIIa and rituximab
Acquired haemophilia associated with clopidogrel; report of two cases
Analysis of predisposing factors and six-month outcomes of DVT management in 668 patients treated with LMWH (tinzaparin) as outpatients
Heparin induced thrombocytopenia (HIT) : a 5-year review at University Hospital Birmingham, UK
Acquired FVIII inhibitor associated with nephrotic syndrome in a child
The effect of citrate and citrate theophylline adenosine dipyridamole (CTAD) anticoagulants on the determination of plasminogen activator inhibitor-1 (PAI-1) antigen
Increased circulating endothelial cells as an index of endothelial damage in congestive heart failure
Abnormal vascular, platelet and coagulation markers in essential thrombocythaemia are not reversed by treatments that reduce the platelet count
The effect of multi-factorial intervention on markers of endothelial damage/dysfunction and thrombogenesis in diabetes mellitus
What is the role of thrombophilia screening in eye disease?
The effect of hormone replacement therapy on the expression of monocyte tissue factor
Self-management of anticoagulation : a randomized trial (SMART)
A study of the effect of introduction of clinical guidelines on the management of major haemorrhage in patients on warfarin
Patient self-testing of INR is a safe and acceptable alternative to laboratory-based testing
The role of medication adherence in warfarin anticoagulation control and its cognitive determinants
The effect of initiation of oral anticoagulation on protein Z and coagulation activation
Bleeding complications of oral anticoagulant therapy : a prospective audit
Health care costs of treating bleeding and other complications associated with warfarin treatment of atrial fibrillation and venous thromboembolism in the UK
Management of anticoagulated patients before and after elective urological surgery
Monitoring low molecular weight heparin in pregnancy : the timing of the peak measurement
Results of a digital web-based exercise for UK NEQAS(H), blood cell and bone marrow morphology
The hypergammaglobinaemia of Gauchers disease is not reversed by enzyme replacement therapy
Abnormal distribution of cell surface receptors in glycosphingolipid storage disorders : an in vitro model of Gaucher's and Fabry disease
Use of the galactomannan ELISA in the detection of invasive aspergillosis : a retrospective review and potential pitfalls in application
Only a minority of age eligible patients with myeloma undergo treatment with autologous transplantation. A population based study of the contributory factors. A combined survey on behalf of The Northern Ireland Regional Haematology Group (NIRHG) and The Newcastle Regional Haematology Group (NRHG)
The impact of the National Screening Program on the affected births and β-thalassaemia mutations in transfusion-dependent thalassaemic patients in Taiwan
Variable recovery of the 3rd international ferritin standard 94/572 shown by UKNEQAS haematinics survey of ferritin immunoassays
Evaluation of DiffMaster Octavia for use on Wright–Geimsa stained blood smears
Introduction of an integrated care pathway for neutropenic sepsis
The use and abuse of haematology investigations in a young stroke population
Genetic screening for haemachromatosis – a cautionary tale
Results of bone marrow biopsy patient satisfaction survey at the Royal Bournemouth Hospital
The use of anagrelide for control of thrombocythaemia at the regional haematology unit, Belfast City Hospital
Results of an open-label study of high-dose liposomal amphotericin B (AmBisome) in the treatment of confirmed fungal infections in high-risk patients
Communication with patients diagnosed with haematological malignancy. On behalf of the Regional Multiprofessional Audit Group
Peripheral blood leucocyte and lymphocyte subpopulations in elderly Kuwaiti subjects
Pseudothrombocytopenia (PTCP) apparent in vitro in ethylene diamine tetra acetic acid (EDTA), sodium citrate and heparin anticoagulants but not by flow cytometric analysis using CD61 antibody
Blood film reports : how often are they acted upon?
Variability in platelet dose and incremental response in haematology patients in the UK
SHOT 6th Annual Report – errors remain the predominant finding
Oral vitamin K does not affect vitamin K-dependent coagulation factors in normal individuals
The incidence and aetiology of anti-c, anti-E and anti-Kell antibodies in antenatal samples across West Yorkshire from January 2000 to June 2002 : time to review blood selection guidelines for transfusion to females?
An audit of blood issue fridge activity
Defective high shear platelet function among platelet donors
Ximelagatran, an oral direct thrombin inhibitor, compared with current standard therapy for acute, symptomatic deep vein thrombosis, with or without pulmonary embolism : the THRIVE Treatment Study
Polycythaemia vera and pregnancy : a review of treatment and outcome of 16 pregnancies in 8 women
Genomic breakpoint cloning and a functional assay of DNA topoisomerase II cleavage reveal translocation mechanism underlying formation of t(15;17) in therapy-related acute promyelocytic leukaemia
T-cell-mediated colitis and bone destruction in a murine model of autoimmunity are both driven by RANK/RANK LIGAND interactions and modulated by recombinant Fc-OPG
Diagnosis and outcome prediction for childhood acute leukaemia by gene expression profiling
Haploidentical transplantation – a single centre experience
Circulating BCR-ABL specific CD8+ cells are detectable in chronic myeloid leukaemia patients and healthy subjects
Rapid and quantitative detection of mutations of the FLT3 gene in AML
Expression of AML1-ETO in human CD34+ cells blocks granulocytic differentiation and increases self-renewal
The relationship between FLT3 mutation status, biological characteristics and outcome in patients with acute promyelocytic leukaemia
Haemorrhagic cystitis and BK virus : association and treatment
Sodium valproate, when combined with all-trans retinoic acid, induces apoptosis and histone acetylation in primary blasts from patients with acute myeloid leukaemia (AML)
Epigenetic inheritance and leukaemogenesis : lessons from the M-CSF receptor gene
Inhibition of the internal tandem duplicated FLT3 receptor by tyrosine kinase inhibitor PKC412 alters DNA repair kinetics and down-regulates DNA repair enzymes, RAD51, DNA PK, PARP, and MSH2
An SCL +19 enhancer targets haematopoietic progenitors and endothelium in the mouse embryo and postnatal mice
Differential HOX gene expression in differentiating myeloid cell lines
CD8-independent, MHC class I-restricted antigen recognition by murine CD4 T cells via transferred T-cell receptors
JUNE-1 is a novel gene involved in erythroid differentiation